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Poliklinik für KieferorthopädieDirektor: Univ.-Prof. Dr. Dr. Heinrich Wehrbein
2019 |
Einrichtungsstatistik
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Forschungsprojekte | 26 |
Publikationen | 8 |
Promotionen | 5 |
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Projektleiter: V De Wilde, Univ.-Prof. Dr. Dr. H Wehrbein
Influence of bisphosphonates and mechanical loading on periostin synthesis of periodontal fibroblasts (HPdLF)The orthodontic dreatment of adult patients is getting more and more popular. Patients with osteoporosis and intake of bisphosphonates are a new challenge for orthodontic treatment. For the orthodontic tooth movement bone-turnover of the alveolar bone is necessary and induced by the applied forces on the teeth. The periodontium and the alveolar bone reacts with bone apposition and resorption. Bisphosphonates do also influence these mechanism of burn turn-over. Periostin is an important adhesionsprotein supporting the cell-matrix-contacts. It plays an important role in the regulation of the remodelling of the periodontium. Aim of this study is to analyze the effects of mechanical loading and bisphosphonates on the periostin synthesis of HPdLF.
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Laufzeit: 2014-2019 |
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Projektleiter: Dr. C Erbe, Univ.-Prof. Dr. Dr. H Wehrbein
A Digital Plaque Imaging Study to Assess the Anti-Plaque Efficacy of Two Marketed DentifricesAbstract: The objective of this study is to assess plaque after using two marketed dentifrices by means of DPIA. This is a single-center, 2-treatment, blinded, parallel group, randomized study design. A sufficient number of adults ages 18+ will be screened to enroll 100 subjects (50 per treatment group) at the acclimation visit. Subjects will have a baseline visit at which they will have an oral soft tissue exam (OST), and one replicate of pre and post brushing DPIA images taken. Then, subjects will be stratified and randomly assigned to one of the two treatment groups at the Product Distribution visit based on DPIA plaque measurements taken at the Baseline visit. After three weeks of treatment, subjects will have two additional separate visits and will have one replicate of pre and post brushing DPIA images taken at each visit
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Laufzeit: 2011-2019 |
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Projektleiter: Dr. C Erbe, Univ.-Prof. Dr. Dr. H Wehrbein
An Exploratory Study to Assess Plaque Reduction of Two Marketed DentifricesThe objective of this study is to assess plaque (primary variable) and salivary metabolites (secondary variable) after using two marketed dentifrices.
This is a randomized, two-treatment, cross-over study with four treatment periods. Up to 36 healthy adult volunteers who have evidence of overnight plaque will be enrolled. Evidence of overnight plaque is based on a screening exercise. Subjects will complete approximate 2 week acclimation period, followed by a 17 days treatment period, and then a 4 day wash-out period. Overnight plaque will be measured by digital plaque image analysis of fluorescein-disclosed plaque. Saliva samples will be collected during acclimation and during the third treatment week of each treatment period. The treatment and wash-out periods will be repeated until Period 4 is complete. Subjects will be randomly assigned to one of four treatment sequences at the Product Distribution visit before Period 1.
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Laufzeit: 2011-2019 |
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Projektleiter: Dr. C Erbe, Univ.-Prof. Dr. Dr. H Wehrbein
A Study to Develop a Panel of Subjects who have Reproducible Dental PlaqueThe objective of this study is to screen for individuals (adults and children) who have reproducible dental plaque. The subjects who have reproducible plaque as measured by digital plaque imaging (DPIA) may be asked to participate in future studies. The study will consists of two parts; detailed objective for each of the parts is listed below under detailed study objectives.
Detailed study objective Part 1:
The objective of this study is to screen for adults who have reproducible dental plaque upon waking in the morning prior to any oral hygiene or consumption
Detailed study objective Part 2:
The objective of this study is to screen for children who have reproducible dental plaque in the afternoon after no morning brushing and no eating/drinking 1 hour prior to the visit.
This is a study to identify adult subjects with reproducible facial plaque before brushing their teeth in the morning. The target population is up to 160 healthy volunteers who will be screened for approximately 70 adult subjects to qualify for Visits 1, 2 and 3. Subjects who repeatedly have a sufficient plaque level on their anterior teeth and are able to brush part of it off will be added to the panel.
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Laufzeit: 2010-2019 |
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Projektleiter: Dr. C Erbe, Univ.-Prof. Dr. Dr. H Wehrbein
Staining Potential of two Marketed Fluoride RinsesAbstract: The objective of this study is to evaluate the stain accumulation potential of two marketed Fluoride rinses in children.
This will be a randomized, parallel group, double-blind, single-center study with two treatment groups comprised of healthy children (10 – 16 years old) with up to 30 subjects per group. A total of up to 60 subjects will participate in this study. At the Baseline visit, subjects will be given an oral exam and a prophylactic cleaning on the twelve anterior teeth. Subjects will be randomly assigned to one of the two treatments. Subjects will then be given a study kit and use it for next two months. Safety and efficacy measurements will be assessed at the Baseline, Week 4 and Week 8 visits. |
Laufzeit: 2011-2022 |
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Projektleiter: Dr. C. Erbe, Univ.-Prof. Dr. Dr. H. Wehrbein
A clinical comparing a power Toothbrush with Smartphone application to manual Toothbrush among adolescents with fixed orthodontic AppliancesThis is a single-center, examiner-blind, 2 week, 2 treatment, parallel group, randomized study design. Approximately sixty (60) adolescent subjects, 13-17 years of age, who show evidence of areas with dental plaque and who are routine manual toothbrush users and possess a Smartphone will be enrolled in this study. Plaque measurements will be taken at three time points: Screening, Baseline, and Week 2 using the Turesky Modified Quigley-Hein Plaque Index (TQHPI).
Subjects will be asked to refrain from all oral hygiene procedures after their morning brushing (which is to be no later than 8 am) prior to all visits (Screening, Baseline, and Week 2). In addition, the subjects will be asked to refrain from eating, drinking, or chewing gum for 2 hours prior to their appointment time. Only small sips of water are permissible. Subjects should refrain from sipping water 45 minutes prior to their scheduled visit.
Subjects will complete a pre and post-use questionnaire with elements of self-assessment (brushing habits, compliance, oral care motivation, self-perceived change in oral health). The subject post-use questionnaire will also include elements of user satisfaction.
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Laufzeit: 2014-2019 |
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Projektleiter: Dr. C. Erbe, Univ.-Prof. Dr. Dr. H. Wehrbein
A clinical evaluation comparing a power Toothbrush with Smartphone application to manual Toothbrush among adolescents with fixed orthodontic AppliancesThis is a single-center, examiner-blind, 6 week, 2 treatment, parallel group, randomized study design. Approximately sixty (60) adolescent subjects, 13-17 years of age, who show evidence of areas with dental plaque and who are routine manual toothbrush users and possess a Smartphone will be enrolled in this study. Plaque measurements will be taken at four time points: Screening, Baseline, Week 2, and Week 6 using the Turesky Modified Quigley-Hein Plaque Index (TQHPI).
Subjects will be asked to refrain from all oral hygiene procedures after their morning brushing (which is to be no later than 8 am) prior to all visits (Screening, Baseline, Week 2, and Week 6). In addition, the subjects will be asked to refrain from eating, drinking, or chewing gum for 2 hours prior to their appointment time. Only small sips of water are permissible. Subjects should refrain from sipping water 45 minutes prior to their scheduled visit.
Subjects will complete a pre and post-use questionnaire with elements of self-assessment (brushing habits, compliance, oral care motivation, self-perceived change in oral health). The subject post-use questionnaire will also include elements of user satisfaction. Specific procedures are detailed below (Table 1).
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Laufzeit: 2015-2019 |
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Projektleiter: Dr. C. Erbe, Univ.-Prof. Dr. Dr. H. Wehrbein
Biofilm characterization from people with different mechanical Plaque removal profileThis was a single-center, double-blind, 2-week, 1-treatment, parallel group study design. Thirty-nine (39) adult subjects, who showed evidence of dental plaque and who were routine manual toothbrush users were enrolled in this study and scheduled for a professional brushing visit. Subjects were instructed to refrain from all oral hygiene procedures for approximately 24 hours prior to their appointments. Of the initial 39, 20 subjects with repeatable plaque levels (at visits 1 and 2) were categorized to have either “hard-to-remove” or “easy-to-remove” plaque (10 subjects each) based on their professional-brushing plaque removal values and were selected for 3 more visits.On-site toothbrushing between pre- and post-brushing plaque assessments were standardized and performed by a dentist. Plaque was measured using DPIA (Digital Plaque Imaging Analysis). At visits 3 to 5 clinical specimens (supragingival plaque samples) were collected from the 20 selected subjects and stored following established techniques for subsequent analysis outside the study protocol. The plaque samples were analyzed for bio-mechanical, compositional and structural properties. At visit 3 subjects received a dental prophylaxis. Approximately 2 weeks later, subjects were invited to measure plaque levels using DPIA. Then they received a professional brushing after which post-brushing DPIA images were taken. Dental plaque was resampled and analyzed for endpoints mentioned above. Subjects then received treatment products (regular manual toothbrush and antibacterial fluoride toothpaste) to use at home for the next 2 weeks. At subject’s final visit (visit-5), the same assessments were conducted as for visit 4.Subjects completed a pre and post-treatment questionnaire about their nutrition behavior. |
Laufzeit: 2015-2019 |
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Projektleiter: Dr. C. Erbe, Prof. Dr. Dr. H. Wehrbein
Clinical Study to assess the Plaque removal efficacy of a new manual toothbrush with small brush headStudy Objective
The objective of this study was to evaluate the efficacy of a new Oral-B manual toothbrush (Cross Action small brush head design) verus a control group (Oral-B Indicator 30 soft) in the reduction of dental plaque among a general adult population using the Turesky Modified Quigley-Hein Index (TQHPI).
Product Usage
Acclimation:
Subjects were instructed to brush their teeth at home twice daily (morning and evening) in their customary manner using the assigned provided test toothbrush and their regular toothpaste for approximately one week prior to their on-site visits.
Periods 1-4
Subjects were instructed to brush their teeth as they normally do with the assigned manual brush. The marketed dentifrice was dispensed by site personnel on a tongue depressor. Subjects brushed their teeth without access to a mirror. Brushing time was recorded in a discrete manner by site staff.
Study Design
This was a single-brushing, 2-treatment, examiner-blind, randomized, 4 period, crossover design. Subjects used each of the two toothbrushes twice. 26 adult subjects were enrolled into the clinical trial based on study criteria. For familiarization purposes, subjects were given their assigned test toothbrush to use at home twice daily for approximately one week prior to each study period visit. Subjects were instructed to refrain from all oral hygiene procedures for approximately 24 hours prior to each of their appointment times. In addition, the subjects were instructed to refrain from eating, drinking, chewing gum or smoking (including smokeless tobacco) for 2 hours prior to their appointment time. Only small sips of water were permissible. Subjects were to refrain from sipping water 45 minutes prior to their scheduled visit.
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Laufzeit: 2018-2023 |
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Projektleiter: Dr. C. Erbe, Univ.-Prof. Dr. Dr. H. Wehrbein
Comparison of aligner therapy versus Herbst treatment in an adolescent populationStudy Objectives
The primary objective of this retrospective study is to determine the outcome of the proclination of the lower incisors during orthodontic therapy between a group treated with aligners (Invisalign Teen®) in combination with Class II elastics (n=20) and a control group in an adolescent population with Class II malocclusion. The control group was treated with casted splint Herbst appliance followed by multibracket appliance (MBA) therapy (n=20).
The secondary objective of this retrospective study is to determine the outcome of the treatment itself during orthodontic therapy between a group treated with aligners (Invisalign Teen®) in combination with Class II elastics (n=20) and a control group treated with casted splint Herbst appliance followed by multibracket appliance (MBA) therapy (n=20) in an adolescent population with Class II malocclusion.
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Laufzeit: 2016-2020 |
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Projektleiter: Dr. C. Erbe
Histological and histomorphometric investigation of the median palatine suture in different age groups - an ex vivo study on human cadaver specimensThe median palatine suture of the maxilla, which extends from the maxillary incisal fossa to the nasal posterior spine, is of great clinical importance and relevance to orthodontists worldwide. A rapid maxillary expansion (RME) is indicated in the presence of a a narrow upper jaw and / or a one- or bilateral crossbite and / or frontal crowding in order to create space as fast as possible in the transversal.
As the patient ages, the so-called transversal resistance of the median palatine suture becomes larger and thus, it becomes increasingly difficult to predict the success of a conservative RME. Therefore, in patients > 18 years, surgically assisted RME is usually preferred to conservative RME.
Assumptions that the increasing ossification of the suture are responsible for this resistance can only be partially verified. Previous studies showed that at the age of 30 years, only a very small portion of the median suture is clearly ossified, which means that there is still a need for considerable examinations / ex vivo studies.
The aim of this study is to use modern histological and histomorphometric methods to analyze the age-related morphological changes of the median palatine suture in cooperation with Prof. Dr. Dr. Dr. Shahram Ghanaati, Senior Consultant and Head of the Research Laboratory (FORM-Lab, Frankfurt Orofacial Regenerative Medicine-Lab), the Department of Oral and Maxillofacial Surgery of the Goethe-University Frankfurt am Main (Director: Univ.-Prof. Dr. Dr. Robert Sader). Further insights into the transversal resistance of the median palatine sutura should be gained. The working hypothesis says that the age-dependent form changes of the suture, the horizontal and transversal interdigitations (twisting or toothing of the bone suture), respectively, could be responsible for this resistance.
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Laufzeit: 2017-2022 |
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Projektleiter: Dr. C. Erbe, Univ.-Prof. Dr. Dr. H. Wehrbein
Study evaluating the oral hygiene status and quality of life of the patient before, during and after the Aligner-Therapy (Invisalign®)The German Oral Health Study IV (DMS IV) from 2005 shows that for 45% of children (age: 12 years) and 58% of adolescents (age: 15 years) an orthodontic treatment has either been carried out or was planned. In addition, a clear decline in the incidence of caries in children and teenagers was reported. 70.1% of the children (age: 12 years) and 46.1% of teenagers (age: 15 years) had caries-free teeth. Nearly 80% of caries cases were experienced by only 26.5% of the teenagers (age: 15 years) (Brauckhoff et al. 2009) [1]. In the overall patient population of the Department of Orthodontics at the Medical University of Mainz, about 80% of patients are treated with fixed orthodontic appliances. Aligner Therapy is also a contemporary procedure for orthodontic treatment. In 2011, approximately 78.000 patients worldwide were treated by Invisalign teen. Dental plaque plays an important role in the development of caries and oral disease. Plaque removal and control are important aspects of oral health establishment and maintenance (Shibly et al., 1995)[2]. Plaque can cause dental demineralisation (WSL - White Spot Lesions), a prerequisite for the onset of caries, and lead to gingivitis (Gorelick et al., 1982, Oogaard B, 1989, Årtun and Brobakken, 1986) [3-5]. Therefore, the main objective of this proposed controlled clinical trial is to assess the quantity of WSL between an aligner treatment group (Invisalign teen) and a control group wearing fixed orthodontic appliances. This study is designed as a prospective, controlled, single-treatment study with 7 study visits. Up to 50 subjects with no history of orthodontic treatment will be enrolled into the study. Subjects who meet the inclusion and exclusion criteria will receive a comprehensive oral examination (OST) to evaluate the oral and perioral region, including hard and soft tissues. Overnight plaque accumulation will be evaluated by means of the modified Quigley Hein Plaque Index (TMQH) at each visit. Gingival Crevicular Fluid (GCF) samples will be collected at Baseline (Screening), 4 weeks, 6 months, 1 year and 1 ½ year after receiving first aligner, 3 months after aligner therapy and 1 year after finishing the aligner therapy. Gingivitis-Index (GI) will be assessed at the same time points as the GCF collection. Quantitative Light Induced Fluorescence (QLF) and White Spot Lesion-Index (WSL) will be assessed at visit 1, 6 months, 1 year and 1 ½ year after receiving first aligner, 3 months after aligner therapy and 1 year after finishing the aligner therapy.
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Laufzeit: 2014-2019 |
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Projektleiter: Dr. C. Erbe, Univ.-Prof. Dr. Dr. H. Wehrbein
The purpose of this study is to assess the plaque removal efficacy of three experimental manual toothbrushes relative to a regular manual toothbrush using the Turesky Modified Quigley-Hein Plaque Index (TQHPI)Overall Study Design and Plan
This is a replicate use single brushing, four-treatment, examiner-blind, randomized, eight period, crossover design. Approximately 20 adult subjects at least 18 years of age, will be enrolled into the clinical trial based on study criteria. Subjects will be instructed to refrain from all oral hygiene procedures for approximately 12 hours prior to their appointments. In addition, the subjects will be instructed to refrain from eating, drinking, chewing gum or smoking (including smokeless tobacco) for 4 hours prior to their appointment time. Only small sips of water are permissible. Subjects should refrain from sipping water 45 minutes prior to their scheduled visit.
Inclusion Criteria
In order to be included in the study, each subject must:
-provide written informed consent and receive a signed copy;
-be at least 18 years of age and mainly use a manual toothbrush;
-be in good general health as determined by the investigator/designee based on a review/update of their medical history;
-have a whole mouth average pre-brushing TQHPI score of ³1.75 at Period-1;
-possess a minimum of 16 scorable teeth with facial and lingual scorable surfaces;
-refrain from all oral hygiene procedures for approximately 12 hours prior to this visit and agree to follow this same restriction prior to all visits;
-refrain from eating, drinking (except small sips of water up until 45 minutes prior to their appointment), chewing gum and using tobacco for at least 4 hours prior to this visit and agree to follow these same restrictions prior to all visits;
-agree not to participate in any other oral care study for the duration of this study;
-agree to delay any elective dentistry, including dental prophylaxis, until study completion and to report any non-study dentistry received during the course of this study;
-agree to refrain from using any non-study toothbrushes, dentifrices, mouth rinses, tooth whitening products or floss for the study duration other than their regular at-home toothbrush and toothpaste used between visits;
-agree to maintain their same regular at-home toothbrush and toothpaste for the study duration;
-agree to return for their scheduled visits and to follow all study procedures.Exclusion Criteria
Subjects are excluded from study participation where there is evidence of:
-Any carious lesions requiring restorative treatment;
-active treatment for periodontitis;
-active orthodontic therapy, and/or have removable denture prosthesis;
-any disease or conditions that could be expected to interfere with examination procedures or with the subject safely completing the study (including allergies to dyes);
-dental prophylaxis any time within the 4 weeks prior of the first visit;
-peri/oral piercings;
-using any antibiotics or a chlorhexidine mouth rinse any time within the 2 weeks prior to this visit.
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Laufzeit: 2016-2022 |
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Projektleiter: Dr. Christina Erbe, Univ.-Prof. Dr. Dr. H. Wehrbein
"Stain", Clinical Study Agreement Procter & Gamble 2017166This is a single-center, unsupervised use, single-treatment study. The study will consist of an up-to 3-week stain induction phase followed by a 3-week treatment (stain removal) phase.
A sufficient number of subjects will be screened to obtain approximately 35 adult volunteers to enroll in the study and begin the 3-week run-in phase. Subjects with existing natural tooth stain will receive an optional dental prophylaxis at the beginning of the study, and will be assigned an acclimation toothbrush and toothpaste, and will rinse with tea solution three times daily and with a chlorhexidine rinse (0.1%) once daily for up to three weeks during the run-in phase.
After the run-in phase, up to 30 qualified subjects (with visible stains on anterior teeth) will continue the study and receive treatment products (whitening toothpaste and regular manual toothbrush) to use twice daily for the 3 weeks treatment phase. Tooth color measurements using DIA will be assessed after stain induction (Baseline) and after 3 weeks of treatment (Week 3). Clinical documentary images will be taken at Baseline and Week 3 visits. Subjects will receive a refresher on their oral hygien e instructions at Visit 4 (Week 1).
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Laufzeit: 2017-2023 |
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Projektleiter: Dr. Christina Erbe, Univ.-Prof. Dr. Dr. Heiner Wehrbein, Dr. Charlene Ecker
Analyse okklusaler Kontakte durch den P-Scan: Validität und Reliabilität eines BissanalyseverfahrensEin kostengünstiges und schnelles Verfahren zur Bissanalyse ist der P-Scan nach Prodinger-Glöckl. Er besteht aus einem hufeisenförmigen drucksensitiven Artikulationspapier und einem dazu kongruenten Vliespapier, die übereinander gelegt und mittels Bissgabel im Patientenmund positioniert werden. In einem ersten Schritt untersucht die Studie die Validität und Reliabilität des P-Scan zunächst in vitro, um den Nutzen für die klinische Anwendung zu überprüfen. In einem zweiten Schritt werdn die Reproduzerbarkeit der okklusalen Kontakte, die Validität und Reliabilität des P-Scan zur Ermittlung der individuellen Okklusionsverhältnisse anhand von in vivo Untersuchungen an Probanden bei maximaler Interkuspidation überprüft. Anschließend wird ein einem dritten Schritt der P-Scan herangezogen, um die Okklusionsverhältnisse von Patienten mit Craniomandibuläerer Dysfunktion vor und nach osteopathischer Behandlung zu beurteilen und den klinischen Nutzen dieser Methode zu bewerten. |
Laufzeit: 2017-2023 |
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Projektleiter: Dr. Dr. C Jacobs, Dr. S Grimm, Univ.-Prof. Dr. Dr. H Wehrbein
Influence of bisphosphonates and mechanical loading on periodontal fibroblasts and osteoblastsBei jeder kieferorthopädisch induzierten Zahnbewegung spielt der Knochenstoffwechsel eine obligate Rolle, da sich der Alveolarknochen abhängig von der Bewegungsrichtung auf- und umbaut. Bestand früher das Patientenklientel größtenteils aus Kindern und Jugendlichen, lassen sich heute immer mehr erwachsene Patienten kieferorthopädisch behandeln. Besonders bei weiblichen Patienten erfolgt häufig die Einnahme von Bisphosphonaten zur Osteroporoseprophylaxe.
Ziel der Studie war es herauszufinden, wie Bisphosphonate die Vitabilität und den Stoffwechsel humaner Osteoblasten und parodontaler Fibroblasten unter statisch mechanischer Zugbelastung in vitro beeinflussen. |
Laufzeit: 2014-2019 |
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Projektleiter: Dr. Dr. Collin Jacobs, Univ.-Prof. Dr. Dr. Heiner Wehrbein
Kenntnisstand der Kieferorthopäden über die Medikamteneinnahme ihrer Patienten (Fragebogenstudie)Heute befinden sich immer mehr erwachsene Patienten in einer kieferorthopädischen Behandlung. Besonders bei weiblichen Patienten erfolgt häufig die Einnahme von Bisphosphonaten zur Osteroporoseprophylaxe. Diverse Medikamente und das Alter der Patienten können die Dauer und den Erfolg der kieferorthopädischen Behandlung beeinträchtigen.
Ziel der Studie ist es, herauszufinden, wie hoch der Anteil an erwachsenen Patienten in der kieferorthopädischen Praxis ist und in wieweit die Behandler über die Medikamenteneinnahme ihrer Patienten informiert sind. Der Fokus wird in dieser Studie auf die Einnahme von Bisphosphonaten gelegt.
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Laufzeit: 2014-2019 |
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Projektleiter: Dr. S. Wriedt, Univ.-Prof. Dr. Dr. H. Wehrbein
Bewertung der skelettalen Klasse I-II im Vergleich klinischer Befund versus FRS-AnalysenProjektskizze: Fernröntgenseitenbild und Modelle von 180 konsekutiven Patienten zu Behandlungsbeginn werden von verschiedenen kieferorthopädischen Behandlern ohne metrische Analyse bezüglich der skelettalen Klasse I-III kategorisiert. Die Werte verschiedener Fernröntgenanalysen, die sich in ihrer Klassifizierung häufig widersprechen, werden dazu in Bezug gesetzt, um die für den kieferorthopädischen Alltag aussagekräftigsten und robustesten Parameter zu ermitteln.
Retrospektive Studie anhand von vorhandenen Unterlagen
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Laufzeit: 2010-2019 |
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Projektleiter: Dr. S. Wriedt, Univ.-Prof. Dr. Dr. H. Wehrbein
Kieferspaltosteoplastik - extraorale Veränderungen in Abhängigkeit von der Menge des eingelagerten Transplantates; eine 3D-StudieDie im Rahmen der Kieferspaltosteoplastik bei Patienten mit LKG-Spalten erhobenen Unterlagen (Modelle, DVT, 3D-Scan, eingebrachte Knochenmenge) werden analysiert, um die intra- und extraoralen Veränderungen zu quantifizieren und zukünftig eine Vorhersage der extraoralen Veränderungen durch die Menge des eingebrachten Knochenmaterials treffen zu können.
Prospektive Studie anhand von vorhandenen Unterlagen
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Laufzeit: 2010-2019 |
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Projektleiter: Dr. S. Wriedt, Univ.-Prof. Dr. Dr. H. Wehrbein
Untersuchung der Aussage verschiedener Indices zur Beurteilung der Modelle von Patienten mit Lippen-Kiefer-Gaumenspalten - eine retrospektive StudieProjektskizze: Ermittlung, ob die automatisierte Erstellung des GOSLON-Index mittels des Dokumentationsprogrammes des AKLKG dem Goldstandard (untersuchungsbedingte Festlegung der Indices: 5y_Index_original (5 Jahre, einseitige Spalte), GOSLON_10y_orig (10 Jahre, einseitige Spalte), BAURU_BCLP_6y (5 Jahre, doppelseitige Spalte) und BAURU_BCLP_9y (10 Jahre, doppelseitige Spalte)) ebenbürtig ist. Welche messbaren Parameter beeinflussen die automatische Erstellung des Index am Stärksten und welche Korrekturen müssen im Programm vorgenommen werden? Wie maßgebend ist der Unterschied zwischen der Laien und der Expertenbeurteilung? Weiterhin sollen zusätzliche Indices/Modifikationen der Indices auf ihre Brauchbarkeit überprüft werden. |
Laufzeit: 2016-2019 |
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Projektleiter: Dr. S. Wriedt, Univ.-Prof. Dr. Dr. H. Wehrbein
Zahn- und Kieferstatus bei Erwachsenen mit Trisomie 21, Ethikkommission der LÄK Rheinland-Pfalz 837.379.14 (9618)Projektskizze: In der Literatur finden sich nur spärliche Angaben über die Häufigkeit zahnärztlicher und kieferorthopädischer Befunde bei Erwachsenen mit Trisomie 21 (Desai 1997; Pilcher 1998). Zum Teil wurden Daten im Rahmen der Untersuchung von allgemein geistig- und/oder körperlich behinderten Menschen erhoben, so dass keine differenzierten Ergebnisse der Gruppe mit Down-Syndrom zu ersehen sind (Dinesh, Arnitha et al. 2003; Winter, Baccaglini et al. 2008).
104 Erwachsene (ab 18 Jahre) mit Trisomie 21 werden klinisch untersucht und bei genügender Kooperation fotografisch dokumentiert.
Es werden bei den Probanden der Gebissbefund (Zahnanzahl, persistierende Milchzähne), sowie der kieferorthopädische (Kreuzbisse, Overbite, Overjet, Engstand oder Lückenbildung, Angle-Klasse) und funktionelle Befund (offene Mundhaltung, Schluckmuster, Zungenlage) erhoben. Außerdem erfolgt eine Befragung der Betreuungspersonen bezüglich zahnärztlicher und kieferorthopädischer Anamnese. Evtl. vorliegende zahnärztliche Röntgenaufnahmen werden angefordert und gescannt.
Anschließend erfolgt bei genügender Kooperationsbereitschaft der Probanden eine intra- und extraorale fotografische Dokumentation.
Die Prävalenz der Einzelbefunde bei den Erwachsenen mit Trisomie 21 soll mit der Prävalenz der Befunde, wie sie in Study of Health in Pomerania (SHIP) 2004 (Hensel, Born et al. 2003) und anderen Literaturstellen (Van der Linden 1983; Harzer 2002; Watted and Teuscher 2003) festgestellt wurden, verglichen werden. Zusätzlich zu den Punktschätzern sollen 95%-Konfidenzintervalle bestimmt werden.
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Laufzeit: 2014-2019 |
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Projektleiter: Dr. Susanne Wriedt, Univ.-Prof. Dr. Dr. H. Wehrbein
Bewertung des vertikalen Gesichtswachstums im Vergleich klinischer Befund versus FRS-AnalyseProjektskizze: Fernröntgenseitenbild und extraorale Bilder von 180 konsekutiven Patienten zu Behandlungsbeginn werden von verschiedenen kieferorthopädischen Behandlern ohne metrische Analyse bezüglich des vertikalen Wachstumstyps kategorisiert. Die Werte verschiedener Fernröntgenanalysen, die sich in ihrer Klassifizierung häufig widersprechen, werden dazu in Bezug gesetzt, um die für den kieferorthopädischen Alltag aussagekräftigsten und robustesten Parameter zu ermitteln.
Retrospektive Studie anhand von vorhandenen Unterlagen
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Laufzeit: 2017-2021 |
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Projektleiter: Dr. Susanne Wriedt, Univ.-Prof. Dr. Dr. H. Wehrbein
Prospektive Studie zur Untersuchung der Lebensqualitöät von Müttern innerhalb des ersten Jahres nach der Geburt eines Kindes mit Lippen-Kiefer-Gaumenspalte, Ethikkommission der LÄK Rheinland-Pfalz 837.055.17 (10889)Projektskizze: Das Ziel der geplanten multizentrischen Studie ist die prospektive Einschätzung der mütterlichen Lebensqualität, des Kohärenzgefühls und der sozialen Unterstützung nach der Geburt eines Kindes mit Lippen-Kiefer-Gaumenspalte. Der zu erfassende Zeitraum des ersten Lebensjahres stellt unserer Erfahrung nach für die betroffenen Eltern eine enorme Belastung dar. Auch weisen Vorbefunde auf die massive Belastung der Eltern von Kindern mit LKG-Spalte hin. Diese gerade für die Entwicklung der Mutter-Kind-Beziehung sensible Phase der ersten zwölf Lebensmonate wird durch die schwere Gesichtsfehlbildung von Kindern mit LKG-Spalten erheblich gestört.
Um Änderungen der mütterlichen Lebensqualität innerhalb des ersten Lebensjahres des Kindes zu erfassen, werden die Daten zu drei verschiedenen Messzeitpunkten erhoben. Zusätzlich erfolgt ein Vergleich mit einer Kontrollgruppe. Hierfür werden Mütter, die ein gesundes Kind zur Welt gebracht haben befragt. Der Vergleich soll mögliche Unterschiede der beiden Gruppen aufzeigen.
Die gesammelten Daten werden zur Analyse des Behandlungsablaufes sowie zur Einschätzung der Versorgungssituation der betroffenen Mütter herangezogen.
Studienleiter: OÄ Dr. Karin Strobel, Dr. Ksenija Belaja, Dr. Theodor Klinker; Kieferorthopädie des Universitätsklinikums Erlangen
Prospektive Studie
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Laufzeit: 2017-2024 |
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Projektleiter: Dr. Susanne Wriedt, Univ.-Prof. Dr. Christina Erbe, Sarah Azimi
Weitere Etablierung der intersisziplinären AKLKG-Datenbank an der Unimedizin Mainz unter Berücksichtigung der 3D-Datensätze DVT, Gesichts- und ModellscanNach Überprüfung der Datenbankabfrage für MKG und KFO und der digitalen Gesichtserfassung und Modellerstellung bezüglich Validität und Reliabilität sollehn nun die Erhebung der Befunde laufender und die Archivierung der Befunde beendeter Behandlungen digitalisiert und anschließend mit schon digital archivierten Daten von Patienten mit LKG-Spalten zusammengeführt werden. Es handelt sich momentan um eine Gruppe von ca. 800 Patienten. Das Ziel ist eine bessere Auffindbarkeit der interdisziplinär erstellten Behandlungsunterlagen zur Verbesserung der Behandlung des einzelnen Patienten (Vernetzung der einzelnen Kliniken) und die Verwendbarkeit der Daten für Multicenter-Studien (wie vom AKLKG intendiert, z. B. German Cleft Network Studie zur prächirurgischen Therapie), sowie zur Verbesserung der Behandlung zukünftiger Patienten (Versorgungsforschung). Durch die digitale Aufbereitung der Unterlagen werden Platzprobleme für Akten- und Modellarchive beseitigt (Papierlose Klinik) |
Literatur: |
Wriedt Susanne, Foersch Moritz, Muhle Jan Daniel, Schmidtmann Irene, Wehrbein Heinrich. Multibracket appliance: impression defaults and their reduction by blocking-out - a three-dimensional study. CLINICAL ORAL INVESTIGATIONS 2016; 20 (2): 365-372 |
Wriedt Susanne, Schmidtmann Irene, Niemann Mareike, Wehrbein Heinrich. Digital 3D image of bimaxillary casts connected by a vestibular scan. JOURNAL OF OROFACIAL ORTHOPEDICS-FORTSCHRITTE DER KIEFERORTHOPADIE 2013; 74 (4): 309-318 |
Laufzeit: 2016-2026 |
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Projektleiter: Dr. Susanne Wriedt, Univ.-Prof. Dr. Dr. H. Wehrbein
Zahn- und Kieferstatus bei Patienten mit KleinwuchsProjektskizze: Außer Einzelfallbeschreibungen weist die wissenschaftliche Literatur keine Erhebungen zur Häufigkeit Zahn- und Kieferfehlstellungen bei kleinwüchsigen Patienten auf. Im Rahmen des jährlichen Kleinwuchsforums des BKMF in Hohenroda sollen die entsprechenden Befunde erhoben werden. Ziel der Untersuchung ist es, aufgrund einer breiteren Datenbasis die typischen wachstumsbedingten kieferorthopädischen Problemfelder bei den verschiedenen Krankheitsbildern zu eruieren.
Prospektive Studie
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Laufzeit: 2017-2021 |
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Projektleiter: Dr. Susanne Wriedt, Univ.-Prof. Dr. Dr. H. Wehrbein
Zahnzahlanomalien bei Patienten mit LKG-Spalten im Patientengut der Universitätsmedizin MainzProjektskizze: Die Prävalenz von Zahnnichtanlagen bei Patienten mit LKG-Spalten wird in der Literatur sehr unterschiedlich von 22 bis 86 % angegeben. In der vorliegenden Studie am Patientengut der Universitätsmedizin Mainz sollte untersucht werde, auf welche Orte sich A- und Hypoplasien verteilen und, ob diese Zahnzahlanomalien Einfluss auf die spätere kieferorthopädische und prothetische Therapie (kieferorthopädischer Lückenschluss versus prothetischer Ersatz) haben.
Die Unterlagen (Röntgenbilder; Krankenakten) von 356 Patienten mit Spaltbildung der Geburtsjahrgänge 1954-2007 wurden zufällig dem Archiv der Poliklinik für Kieferorthopädie der Universitätsmedizin Mainz entnommen. Es erfolgte die Extraktion der Parameter: Spaltart; Orte und Anzahl der Hypoplasien und Aplasien; Zeitpunkt der Operationen; Angle-Klasse, Overjet und Overbite zu Beginn der kieferorthopädischen Behandlung; Art der Therapie (prothetischer versus kieferorthopädischer Lückenschluss; Art der prothetischen Versorgung; Notwendigkeit von Umstellungsosteotomien). Die Berechnung der deskriptiven Statistik erfolgte mit dem Programm SPSS23.
Retrospektive Studie anhand von vorhandenen Unterlagen
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Laufzeit: 2017-2020 |
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Erbe Christina, Jacobs Collin, Klukowska Malgorzata, Timm Hans, Grender Julie, Wehrbein Heinrich
Autoren der Einrichtung:
Erbe Christina, Jacobs Collin, Wehrbein Heinrich
A randomized clinical trial to evaluate the plaque removal efficacy of an oscillating-rotating toothbrush versus a sonic toothbrush in orthodontic patients using digital imaging analysis of the anterior dentition ANGLE ORTHODONTIST. 2019; 89 (3): 385-390 Article
Datensatz in Web of Science®
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Erbe Christina, Klukowska Malgorzata, Timm Hans C., Barker Matthew L., van der Wielen Janneke, Wehrbein Heinrich
Autoren der Einrichtung:
Erbe Christina, van der Wielen Janneke, Wehrbein Heinrich
A randomized controlled trial of a power brush/irrigator/mouthrinse routine on plaque and gingivitis reduction in orthodontic patients ANGLE ORTHODONTIST. 2019; 89 (3): 378-384 Article
Datensatz in Web of Science®
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Erbe Christina, Klees Violetta, Braunbeck Fabienne, Ferrari-Peron Priscila, Ccahuana-Vasquez Renzo A., Timm Hans, Grender Julie, Cunningham Pamela, Adam Ralf, Wehrbein Heinrich
Autoren der Einrichtung:
Erbe Christina, Klees Violetta, Braunbeck Fabienne, Ferrari-Peron Priscila, Wehrbein Heinrich
Comparative assessment of plaque removal and motivation between a manual toothbrush and an interactive power toothbrush in adolescents with fixed orthodontic appliances: A single-center, examiner-blind randomized controlled trial AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS. 2019; 155 (4): 462-472 Article
Datensatz in Web of Science®
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Grieb Dominik, Meila Dan, Greling Bjoern, Jacobs Collin, Hechtner Marlene, Martin-Schlunz-Hendann ?, Brassel Friedhe M.
Autoren der Einrichtung:
Jacobs Collin
Weitere Autoren des Fachbereichs:
Hechtner Marlene
Craniofacial venous malformations treated by percutaneous sclerotherapy using polidocanol: a single-center experience ACTA RADIOLOGICA. 2019; 60 (5): 593-601 Article
Datensatz in Web of Science®
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Ohlendorf Daniela, Doerry Charlotte, Fisch Vanessa, Schamberger Sebastian, Erbe Christina, Wanke Eileen M., Groneberg David A.
Autoren der Einrichtung:
Erbe Christina
Standard reference values of the postural control in healthy young female adults in Germany: an observational study BMJ OPEN. 2019; 9 (6): Article
Datensatz in Web of Science®
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Symmank Judit, Zimmermann Sarah, Goldschmitt Jutta, Schiegnitz Eik, Wolf Michael, Wehrbein Heinrich, Jacobs Collin
Autoren der Einrichtung:
Zimmermann Sarah, Wehrbein Heinrich
Weitere Autoren des Fachbereichs:
Goldschmitt Jutta, Schiegnitz Eik
Mechanically-induced GDF15 Secretion by Periodontal Ligament Fibroblasts Regulates Osteogenic Transcription SCIENTIFIC REPORTS. 2019; 9: Article
Datensatz in Web of Science®
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Wieczorek Katja, Harzer Winfried, Wehrbein Heinrich, Moergel Maximilian, Kunkel Martin, Jung Britta A.
Autoren der Einrichtung:
Wehrbein Heinrich
Weitere Autoren des Fachbereichs:
Moergel Maximilian
Predictive values of resonance frequency analysis as a diagnostic tool in palatal implant loss ANGLE ORTHODONTIST. 2019; 89 (5): 721-726 Article
Datensatz in Web of Science®
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Willershausen Ines, Erbe Christina, Al-Maawi Sarah, Orlowska Anna, Wehrbein Heiner, Ghanaati Shahram
Autoren der Einrichtung:
Erbe Christina, Wehrbein Heiner
Development of a novel histological and histomorphometric evaluation protocol for a standardized description of the mid-palatal suture - An ex vivo study JOURNAL OF ANATOMY. 2019; 235 (1): 180-188 Article
Datensatz in Web of Science®
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Lina Vanessa Krull
Perzeption ästhetischer Kieferorthopädischer Apparaturen: Eine Eye- Tracking- und Fragebogenstudie
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Ivana Marinello
Behandlung mit Alignern im Frontzahnbereich
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Ambili Roselina Mundethu
Debonding of Polycrystalline ceramic brackets using Er, Cr: YSGG laser: An in-Vitro study
Entbänderung von Polykristallinen Keramikbrackets mittels Er, Cr: YSGG Laser: eine In-Vitro Studie
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Lisa Marie Steuer
Quantitative Analyse von White Spot Läsionen mit dem Enamel Decalcification Index und quantitativer lichtindzierter Fluoreszenzmessung während der festsitzenden kieferorthopädischen Behandlung Jugendlicher mit Multibracket-Apparatur: ein in-vivo-Vergleich
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Mareike Rita Wehrheim
Verfärbungsrate und Stabilität neuartiger Bögen mit Weißbeschichtung
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