Institute of Immunology

Direktor: Univ.-Prof. Dr. Hansjörg Schild

2015

Facility Statistics
External Funds in €2,469,730
Publications45

Research Projects
Project leader: Prof. Dr. Tobias Bopp, Univ.-Prof. Dr. Frauke Zipp

CRC-TR-128, Project B4: Impact of antigen-presenting cells on T cell responses in chronic neuroinflammation

Project B4: Impact of antigen-presenting cells on T cell responses in chronic neuroinflammation

Duration: 2012-2016
Project leader: Prof. Dr. Tobias Bopp, PD Dr. Christian Becker

Development and testing of nanoparticles for inhibition of cAMP-mediated immunosuppression of malignant melanoma

SFB 1066/1, Teilprojekt B08

Duration: 2013-2017
Project leader: Univ.-Prof. Dr. Tobias Bopp

In-vitro Analyse der Wirksamkeit von BT061 in human CD4 transgenic Maus

In-vitro Analyse der Wirksamkeit von BT061 in human CD4 transgenic Maus

Duration: 2014-2015
Project leader: Univ.-Prof. Dr. Tobias Bopp, Univ.-Prof. Dr. Edgar Schmitt

Transcription factors of murine regulatory T cells and suppressed CD4+ T cells: Identification and functional analyses (DFG)

DFG BO 3306/1-1

Transkriptionelle Regulation in murinen regulatorischen T-Zellen und supprimierten T-Zellen: Identifizierung und funktionelle Analyse
 

Duration: 2014-2016
Project leader: Dr. Matthias Klein

MAIFOR

MAIFOR

Duration: 2013-2015
Project leader: Dr. HC Probst

Analysis of the mechanisms involved in functional impairment of cytotoxic T cells during chronic viral infection (DFG)

DFG PR1184/2-1

Analysis of the mechanisms involved in functional impairment of cytotoxic T cells during chronic viral infection

Duration: 2010-2015
Project leader: Dr. HC Probst

MAIFOR (Dr. HC Probst)

MAIFOR (Dr. HC Probst)

Duration: 2013-2015
Project leader: Univ.-Prof. Dr. Markus Radsak

A role for polymorphonuclear neutrophils in the pathogenesis of the anti-phospholipid syndrome

The anti-phospholipid syndrome (APS) is a systemic autoimmune disease characterized by the occurrence of anti-phospholipid specific antibodies (aPL) and recurrent thrombosis or recurrent fetal losses in female patients. In this context, complement activation plays an important role in the pathophysiology of APS. As suggested by mouse models, this in turn activates neutrophils (PMN) mediating trophoblast injury by the release of reactive oxygen species. PMNs are an essential cell type for the initiation of experimental venous thrombosis. Thus, activation of PMNs by aPL may be a critical molecular event during the development of thrombosis in APS patients. We recently demonstrated that aPL alone are able to directly induce activation of PMN effector functions, while the additional presence of Toll-like receptor (TLR) agonists, such as LPS or Pam3Cys, strongly enhances these effects, indicating a synergistic activation pathway of aPL and microbial products. This is corroborated by additional results demonstrating an influence of aPL on TLR7/8 signalling in plasmacytoid dendritic cells and monocytes further supporting the notion that aPL directly interact with innate inflammatory cells. We plan to further characterize the activation status of PMN under inflammatory conditions in the presence of aPL and the resulting impact on APS symptoms. This will provide novel insights for a better understanding of the pathophysiology of APS.
The aim of this project will be to analyze the receptors and pathways involved in aPL induced PMN activation using monoclonal aPL (clones HL5B/HL7G, provided by the Institute of Clinical Chemistry and Laboratory Medicine). In addition, we will investigate in detail PMN activation induced by aPL and additional inflammatory conditions in the presence or absence of TLR agonists in comparison to monocytic cells. For this, we will use established PMN effector assays and employ Western blot as well as phospho-flow analyses to screen for important PMN signalling molecules. To determine the impact of aPL/TLR ligand-activated PMN on the procoagulant activity, we will cooperate with D. Manukyan (CTH Virchow fellow, Institute of Laboratory Medicine and Clin. Chemistry) and CTH platform 4. For validation we will also include studies with IgG fractions of APS patients as well as PMN from APS patients (in cooperation with I. Scharrer, IIIrd Dept. of Medicine).
This project contributes to an improved understanding of the pathophysiology of APS and integrates basic scientific questions with translational patient related studies creating a direct connection in the scope of the CTH.
 

Duration: 2014-2015
Project leader: Prof. Dr. Markus Radsak, PD Dr. Michael Stassen

Transcutaneous immunization: Mechanisms of intracellular networks of the skin (TRR156, A05)

Wir haben eine Methode zur transkutanen Immunisierung (TCI) etabliert, bei der der TLR7-Agonist Imiquimod zusammen mit einem CD8 T-Zell Epitop auf intakte Maushaut aufgetragen wird. In Fortführung unserer bisherigen Arbeit untersuchen wir die Funktionen von myeloischen Zellen in der Haut, wie Dendritische Zellen, Makrophagen, Neutrophile und Mastzellen, um Zellen und Mediatoren zu identifizieren, welche den Erfolg der TCI positiv oder negativ beeinflussen. Als Perspektive möchten wir die TCI und insbesondere die Induktion von T-Gedächtniszellen optimieren.

Duration: 2015-2019
Project leader: Prof. Dr. Krishna Rajalingam, Univ.-Prof. Dr. Frauke Zipp

CRC-TR-128, Project B9: Molecular Mechanisms of immune-mediated neurodegeneration

Molecular Mechanisms of immune-mediated neurodegeneration

Duration: 2012-2016
Project leader: Univ.-Prof. Dr. Krishnaraj Rajalingam

Elucidation of the molecular mechanisms of Caspase-2 activation (DFG)

Aufklärung der molekularen Mechanismen zur Caspase-2 Aktivierung.

Duration: 2013-2016
Project leader: Univ.-Prof. Dr. Krishnaraj Rajalingam

Gutenberg Forschungskolleg (GFK) Fellowship

GFK-Fellowship

Duration: 2015-2019
Project leader: Univ.-Prof. Dr. Krishnaraj Rajalingam

Heisenberg (DFG)

Heisenberg (DFG)

Duration: 2014-2019
Project leader: Univ.-Prof. Dr. Krishnaraj Rajalingam

Role of IAP-IAP complexes (BIF Plus 3 Project)

Role of IAP-IAP complexes (BIF Plus 3 Project)

Duration: 2015-2016
Project leader: Prof. Dr. Ugur Sahin, Prof. Dr. Edgar Schmitt

Targeted Inflammation ¿ Verbesserung der Immigration von Leukozyten in das Tumorbett durch Polymer-vermittelte Aktivierung des Tumorendothels (SFB 1066)

SFB 1066/1, Teilprojekt B01

Duration: 2013-2017
Project leader: Univ.-Prof. Dr. Hansjörg Schild

Entwicklung eines mikrofluidischen Systems (artifizieller Blutkreislauf) zur quantitativen Analyse der Interaktion von Nanopartikeln mit Blutbestandteilen (Stiftung RP)

Entwicklung eines mikrofluidischen Systems (artifizieller Blutkreislauf) zur quantitativen Analyse der Interaktion von Nanopartikeln mit Blutbestandteilen

Duration: 2013-2015
Project leader: Univ.-Prof. Dr. Hansjörg Schild, Dr. Hans Christian Probst

Functional analysis of skin subsets of dendritic cells in T cell priming and tolerance using inducible transgenic mice that allow subset specific antigen expression (TRR156, B02)

Funktionelle Analyse der Subpopulationen dendritischer Zellen der Haut mittels subpopulations-spezifischer Antigen Expression in induzierbaren transgenen Mäusen

Duration: 2015-2019
Project leader: Univ.-Prof. Dr. Hansjörg Schild, Univ.-Prof. Dr. Stephan Grabbe

Polymer-mediated in situ activation of dendritic cells for tumor immunotherapy

SFB 1066/1, Teilprojekt B04

Duration: 2013-2017
Project leader: Univ.-Prof. Dr. Edgar Schmitt, Univ.-Prof. Dr. Tobias Bopp

Transcription factors of murine regulatory T cells and suppressed CD4+ T cells: Identification and functional analyses

DFG SCHM 1014/7-1

Duration: 2014-2016
Project leader: PD Dr. M Stassen

Forschungszentrum Immunologie (FZI), Asthma Core Facility CF1

FZI-Asthma Core Facility (CF1)

Duration: 2014-2017
Project leader: PD Dr. Michael Stassen

Interactions between mast cells and neutrophils in murine models of acute inflammation (DFG)

Neutrophile Granulocyten sind ein zentraler Bestandteil der angeborenen Immunabwehr gegen pathogene Mikroorganismen. Verschiedene Mausmodelle für akute Entzündungen erlauben den Schluß, daß die rasche Rekrutierung neutrophiler Granulocyten in das entzündete Gewebe durch Mastzellen ausgelöst werden kann. Nach ihrer Aktivierung können Mastzellen sehr schnell gespeicherte und neu synthetisierte Mediatoren freisetzen, welche auf die Blutgefäße auskleidenden Endothelzellen wirken. Diese Aktivierung des Endothels ist eine Grundvoraussetzung für das Andocken und die Extravasation neutrophiler Granulocyten. In diesem Zusammenhang zeigen unsere Pilotstudien im Maussystem, daß Mastzellen auch direkt die Aktivierung neutrophiler Granulocyten in fördern können. Insbesondere die Neutrophilen Phagocytose wird in Gegenwart aktivierter Mastzellen erheblich verstärkt. Interessanterweise zeigen unsere bisherigen Daten, daß aktivierte neutrophile Granulocyten ihrerseits ko-aktivierende Signale für Mastzellen liefern können, bezogen auf Degranulation und die Produktion von Mastzell-Cytokinen. Dieses Wechselspiel zwischen Mastzellen und neutrophilen Granulocyten ist bisher weitgehend unbekannt und soll Gegenstand des vorliegenden Projektes sein. Untersuchungen an isolierten Populationen beider Zelltypen in vitro sollen Aufschluß über die zu Grunde liegenden Mechanismen dieses Wechselspiels liefern. Dieser Ansatz soll durch Tierversuche untermauert werden, in denen verschiedene Stämme mastzelloser Mäuse in Modellen für akute Entzündungen eingesetzt werden.

Duration: 2012-2017
Project leader: Dr. Stefan Tenzer, Univ.-Prof. Dr. Hansjörg Schild

e:Bio - Module 1: Express2Present - an integrative model to predict MHC class-I presented peptide ligands (BMBF)

e:Bio - Modul I - Verbundprojekt: Expression2Presentation: ein integratives Modell zur Prädikation von MHC Klasse I-präsentierten Peptidliganden

Duration: 2013-2016
Project leader: Dr. Stefan Tenzer

Forschungszentrum Immunologie (FZI), Core Facility Massenspektrometrie CF7

FZI-Massenspektrometrie Core Facility (CF7)

Duration: 2014-2017
Project leader: Dr. Stefan Tenzer

Funktionelle Charakterisierung der zellspezifischen Unterschiede von L. major Phagolysosomen in Makrophagen und dendritischen Zellen (DFG)

Funktionelle Charakterisierung der zellspezifischen Unterschiede von L. major Phagolysosomen in Makrophagen und dendritischen Zellen

Duration: 2014-2017
Project leader: Dr. Stefan Tenzer, Univ.-Prof. Dr. Ruth Esther von Stebut-Borschitz

Identification and characterization of L. major T cell epitopes based on quantitative proteomics (DFG)

Leishmaniasis is a disease observed after inoculation of a protozoan parasite into the skin inducing symptoms ranging from local, self-limiting lesions to life-threatening visceralisation. Protective immunity against Leishmania is mediated by antigen specific CD8+ and CD4+ T cells which are primed by dendritic cells infected with the amastigote life form. As currently no vaccine exists, identification of protective T cell epitopes is essential, but so far only two CD4 epitopes have been characterized. Therefore, we aim to identify and characterize potential protective T cell epitopes derived from Leishmania major. Towards this purpose, we will partition the proteome of L. major promastigote and amastigote life forms by chromatographic and ultracentrifugation techniques. Using label-free quantitative mass spectrometry, we will identify abundant and/or stage-specific proteins constituting potential sources for T cell epitopes. We will then select epitope candidates applying in silico predictions for MHC binding affinity or by peptide library screening. Candidates will then be assayed for immunoreactivity both in vitro (binding affinity to MHC class I and II, induction of cytokine release and proliferation of T cells), and in vivo (immunizations) followed by detailed analyses of immunodominance, mechanisms of antigen uptake, processing of parasite life form-specific epitopes, and potential immune evasion mechanisms.

Duration: 2012-2016
Project leader: Univ.-Prof. Dr. Frauke Zipp

CRC-TR-128: Initiating/effector versus regulatory mechanisms in Multiple Sclerosis – progress towards tackling the disease

Multiple Sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system (CNS) in the western world and it leads to devastating disability in young adults, with only limited treatment options currently available. The socioeconomic burden of this disease is tremendous, since healthcare costs are very high and it affects decisions young patients must make for the rest of their lives. Findings in patients are a complex composite of inflammation (with demyelination, remyelination, axonal/neuronal damage) typically in subcortical, but also cortical, disseminated lesions as well as neurodegeneration. Remissions of clinical relapses point to repair capacities of the CNS, which exhibits strong interindividual and course dependent differences.

Spokesperson: Prof. Frauke Zipp (Department of Neurology)

Projects with a co-PI from Mainz
  • A3: G protein-mediated signaling in immune cells: implications for neuroinflammation (Wettschureck/Kurschus)
  • B4: Impact of antigen-presenting cells on T cell responses in chronic neuroinflammation (Zipp/Bopp)
  • B5: Imaging of damage and repair in MS patients – Impact of new lesions on network activity (Deichmann/Zipp)
  • B9: Molecular mechanisms underlying T cell mediated neuronal damage (Zipp/Rajalingam)
  • A7: Sources and functional significance of IL-6 in shaping autoreactive T cell responses in the peripheral immune compartment and the CNS (Waisman/Korn)
  • A9: Analysis and therapeutic modification of T cell responses in multiple sclerosis (Jonuleit/Wiendl)
  • B7: Oligodendrocyte progenitor cells in de- and remyelination: release of differentiation brakes in mouse and human cells (Trotter-Kyewski/Kuhlmann)
  • Z2: Clinical translational unit: Immunobiology of distinct patient phenotypes (Wiendl/Hemmer/Hohlfeld/Zipp)

Duration: 2012-2016

Publications

Becker Marc, Lemmermann Niels A. W., Ebert Stefan, Baars Pamela, Renzaho Angelique, Podlech Jurgen, Stassen Michael, Reddehase Matthias J.
Autoren der Einrichtung: Becker Marc, Baars Pamela, Stassen Michael
Mast cells as rapid innate sensors of cytomegalovirus by TLR3/TRIF signaling-dependent and -independent mechanisms
2015; 12 (2): 192-201

Bodor Josef, Bohn Tozska, Bopp Tobias, Schmitt Edgar
Autoren der Einrichtung: Bodor Josef, Bohn Tozska, Bopp Tobias, Schmitt Edgar
Transcriptional regulation of cytokines in regulatory T cell-mediated suppression and its role in antitumor therapy
2015; 76 (1): 106-106

Bohm Livia, Maxeiner Joachim, Meyer-Martin Helen, Reuter Sebastian, Finotto Susetta, Klein Matthias, Schild Hansjorg, Schmitt Edgar, Bopp Tobias, Taube Christian
Autoren der Einrichtung: Bohm Livia, Maxeiner Joachim, Klein Matthias, Schild Hansjorg, Schmitt Edgar, Bopp Tobias
IL-10 and Regulatory T Cells Cooperate in Allergen-Specific Immunotherapy To Ameliorate Allergic Asthma
2015; 194 (3): 887-897

Bruttger Julia, Karram Khalad, Woertge Simone, Regen Tommy, Marini Federico, Hoppmann Nicola, Klein Matthias, Blank Thomas, Yona Simon, Wolf Yochai, Mack Matthias, Pinteaux Emmanuel, Mueller Werner, Zipp Frauke, Binder Harald, Bopp Tobias, Prinz Marco, Jung Steffen, Waisman Ari
Autoren der Einrichtung: Klein Matthias, Bopp Tobias
Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System
2015; 43 (1): 92-106

Bruttger J., Karram K., Woertge S., Regen T., Marini F., Hoppmann N., Klein M., Blank T., Yona S., Wolf Y., Pinteaux E., Mack M., Mueller W., Zipp F., Binder H., Bopp T., Prinz M., Jung S., Waisman A.
Autoren der Einrichtung: Klein M., Bopp T.
Local self-renewing of microglia is dependent on Interleukin-1 signaling
2015; 63: E198-E199

Buescher Nicole, Paulus Christina, Nevels Michael, Tenzer Stefan, Plachter Bodo
Autoren der Einrichtung: Tenzer Stefan
The proteome of human cytomegalovirus virions and dense bodies is conserved across different strains
2015; 204 (3): 285-293

Cai Hui, Palitzsch Bjoern, Hartmann Sebastian, Stergiou Natascha, Kunz Horst, Schmitt Edgar, Westerlind Ulrika
Autoren der Einrichtung: Stergiou Natascha, Schmitt Edgar
Antibody Induction Directed against the Tumor-Associated MUC4 Glycoprotein
2015; 16 (6): 959-967

Crauwels Peter, Bohn Rebecca, Thomas Meike, Gottwalt Stefan, Jaeckel Florian, Kraemer Susi, Bank Elena, Tenzer Stefan, Walther Paul, Bastian Max, van Zandbergen Ger
Autoren der Einrichtung: Tenzer Stefan, van Zandbergen Ger
Apoptotic-like Leishmania exploit the host's autophagy machinery to reduce T-cell-mediated parasite elimination
2015; 11 (2): 285-297

Crauwels Peter, Bohn Rebecca, Thomas Meike, Gottwalt Stefan, Jaeckel Florian, Kraemer Susi, Bank Elena, Tenzer Stefan, Walther Paul, Bastian Max, van Zandbergen Ger
Autoren der Einrichtung: Tenzer Stefan, van Zandbergen Ger
Apoptotic-like Leishmania exploit the host's autophagy machinery to reduce T-cell mediated parasite elimination (vol 11, pg 285, 2015)
2015; 11 (8): 1439-1439

Dietze-Schwonberg K., Kostka S. Lopez, Stassen M., Kautz-Neu K., von Stebut E.
Autoren der Einrichtung: Stassen M.
Role of mast cells during Leishmania (L.) major infections depends on genetic background
2015; 24 (3): E27-E28

Dopheide Joern F., Scheer Martin, Doppler Christopher, Obst Viviane, Stein Pamela, Vosseler Markus, Abegunewardene Nico, Gori Tommaso, Muenzel Thomas, Daiber Andreas, Radsak Markus P., Espinola-Klein Christine
Autoren der Einrichtung: Stein Pamela
Change of walking distance in intermittent claudication: impact on inflammation, oxidative stress and mononuclear cells: a pilot study
2015; 104 (9): 751-763

Dubrez Laurence, Rajalingam Krishnaraj
Autoren der Einrichtung: Rajalingam Krishnaraj
IAPs and cell migration
2015; 39: 124-131

Epp K., Schaefer L., Theobald M., Bopp T., Meyer R., Wagner E. M.
Autoren der Einrichtung: Bopp T.
Acute GvHD after Alemtuzumab based conditioning regimen correlates with persistence of GPI-anchor negative, functionally altered regulatory T cells
2015; 50: S51-S51

Fronk Petra, Hartmann Hermann, Bauer Margarita, Solem Even, Jaenicke Elmar, Tenzer Stefan, Decker Heinz
Autoren der Einrichtung: Tenzer Stefan
Polyphenoloxidase from Riesling and Dornfelder wine grapes (Vitis vinifera) is a tyrosinase
2015; 183: 49-57

Glaffig M., Palitzsch B., Stergiou N., Schuell C., Strassburger D., Schmitt E., Frey H., Kunz H.
Autoren der Einrichtung: Stergiou N., Schmitt E.
Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers
2015; 13 (40): 10150-10154

Hartmann Sebastian, Nuhn Lutz, Palitzsch Bjoern, Glaffig Markus, Stergiou Natascha, Gerlitzki Bastian, Schmitt Edgar, Kunz Horst, Zentel Rudolf
Autoren der Einrichtung: Stergiou Natascha, Gerlitzki Bastian, Schmitt Edgar
CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines
2015; 4 (4): 522-527

Hasibeder Astrid, Stein Pamela, Brandwijk Ricardo, Schild Hansjoerg, Radsak Markus P.
Autoren der Einrichtung: Schild Hansjoerg
Evaluation and Validation of the Detection of soluble Triggering Receptor Expressed on Myeloid Cells 1 by Enzyme-linked immunosorbent Assay
2015; 5:

Hasibeder Astrid, Pruefer Steve, Ebner Katharina, Reuter Sebastian, Stein Pamela, Scharrer Inge, Banno Fumiaki, Stassen Michael, Schild Hansjoerg, Jurk Kerstin, Bosmann Markus, Radsak Markus P.
Autoren der Einrichtung: Pruefer Steve, Stassen Michael, Schild Hansjoerg
Neutrophil Recruitment Is Regulated By Adamts-13 in a Murine Model of Invasive Aspergillosis
2015; 126 (23):

Jaeckels Nadine, Tenzer Stefan, Rosch Achim, Scholten Gerhard, Decker Heinz, Fronk Petra
Autoren der Einrichtung: Tenzer Stefan
beta-Glucosidase removal due to bentonite fining during wine making
2015; 241 (2): 253-262

Johannes Manuel, Reindl Maximilian, Gerlitzki Bastian, Schmitt Edgar, Hoffmann-Roeder Anja
Autoren der Einrichtung: Gerlitzki Bastian, Schmitt Edgar
Synthesis and biological evaluation of a novel MUC1 glycopeptide conjugate vaccine candidate comprising a 4'-deoxy-4'-fluoro-Thomsen-Friedenreich epitope
2015; 11: 155-161

Klein Matthias, Bruehl Till-Julius, Staudt Valerie, Reuter Sebastian, Grebe Nadine, Gerlitzki Bastian, Hoffmann Markus, Bohn Toszka, Ulges Alexander, Stergiou Natascha, De Graaf Jos, Loewer Martin, Taube Christian, Becker Marc, Hain Tobias, Dietzen Sarah, Stassen Michael, Huber Magdalena, Lohoff Michael, Chagas Andrezza Campos, Andersen John, Kotal Jan, Langhansova Helena, Kopecky Jan, Schild Hansjoerg, Kotsyfakis Michalis, Schmitt Edgar, Bopp Tobias
Autoren der Einrichtung: Klein Matthias, Bruehl Till-Julius, Staudt Valerie, Grebe Nadine, Gerlitzki Bastian, Hoffmann Markus, Bohn Toszka, Ulges Alexander, Stergiou Natascha, Becker Marc, Hain Tobias, Dietzen Sarah, Stassen Michael, Schild Hansjoerg, Schmitt Edgar, Bopp Tobias
Tick Salivary Sialostatin L Represses the Initiation of Immune Responses by Targeting IRF4-Dependent Transcription in Murine Mast Cells
2015; 195 (2): 621-631

Kuharev Jorg, Navarro Pedro, Distler Ute, Jahn Olaf, Tenzer Stefan
Autoren der Einrichtung: Kuharev Jorg, Navarro Pedro, Distler Ute, Tenzer Stefan
In-depth evaluation of software tools for data-independent acquisition based label-free quantification
2015; 15 (18): 3140-3151

Landgraf Lisa, Christner Carolin, Storck Wiebke, Schick Isabel, Krumbein Ines, Daehring Heidi, Haedicke Katja, Heinz-Herrmann Karl, Teichgraeber Ulf, Reichenbach Juergen R., Tremel Wolfgang, Tenzer Stefan, Hilger Ingrid
Autoren der Einrichtung: Storck Wiebke, Tenzer Stefan
A plasma protein corona enhances the biocompatibility of Au@Fe3O4 Janus particles
2015; 68: 77-88

Langhansova H., Bopp T., Schmitt E., Kopecky J.
Autoren der Einrichtung: Bopp T., Schmitt E.
Tick saliva increases production of three chemokines including monocyte chemoattractant protein-1, a histamine-releasing cytokine
2015; 37 (2): 92-96

Luessi Felix, Kraus Stefan, Trinschek Bettina, Lerch Steffen, Ploen Robert, Paterka Magdalena, Roberg Torsten, Poisa-Beiro Laura, Klotz Luisa, Wiendl Heinz, Bopp Tobias, Jonuleit Helmut, Jolivel Valerie, Zipp Frauke, Witsch Esther
Autoren der Einrichtung: Bopp Tobias
FTY720 (fingolimod) treatment tips the balance towards less immunogenic antigen-presenting cells in patients with multiple sclerosis
2015; 21 (14): 1811-1822

Maus Frank, Sakry Dominik, Biname Fabien, Karram Khalad, Rajalingam Krishnaraj, Watts Colin, Heywood Richard, Krueger Rejko, Stegmueller Judith, Werner Hauke B., Nave Klaus-Armin, Kraemer-Albers Eva-Maria, Trotter Jacqueline
Autoren der Einrichtung: Rajalingam Krishnaraj
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2
2015; 10 (9):

McEwan David G., Richter Benjamin, Claudi Beatrice, Wigge Christoph, Wild Philipp, Farhan Hesso, McGourty Kieran, Coxon Fraser P., Franz-Wachtel Mirita, Perdu Bram, Akutsu Masato, Habermann Anja, Kirchof Anja, Helfrich Miep H., Odgren Paul R., Van Hul Wim, Frangakis Achilleas S., Rajalingam Krishnaraj, Macek Boris, Holden David W., Bumann Dirk, Dikic Ivan
Autoren der Einrichtung: Rajalingam Krishnaraj
PLEKHM1 Regulates Salmonella-Containing Vacuole Biogenesis and Infection
2015; 17 (1): 58-71

Moritz Christian P., Eckstein Eugenia, Tenzer Stefan, Friauf Eckhard
Autoren der Einrichtung: Tenzer Stefan
Neuroproteomics in the auditory brainstem: Candidate proteins for ultrafast and precise information processing
2015; 64: 9-23

Moritz Christian P., Eckstein Eugenia, Tenzer Stefan, Friauf Eckhard
Autoren der Einrichtung: Tenzer Stefan
Neuroproteomics in the auditory brainstem: Candidate proteins for ultrafast and precise information processing (vol 64, pg 9, 2015)
2015; 67: 144-144

Oeser K., Maxeiner J., Symowski C., Stassen M., Voehringer D.
Autoren der Einrichtung: Maxeiner J., Stassen M.
T cells are the critical source of IL-4/IL-13 in a mouse model of allergic asthma
2015; 70 (11): 1440-1449

Patzig J., Tenzer S., Kusch K., Dibaj P., Mobius W., Schaeren-Wiemers N., Nave K. -A., Werner H.
Autoren der Einrichtung: Tenzer S.
Proteomic approach to myelin-related neuropathology
2015; 63: E23-E23

Podlech Juergen, Ebert Stefan, Becker Marc, Reddehase Matthias J., Stassen Michael, Lemmermann Niels A. W.
Autoren der Einrichtung: Becker Marc, Stassen Michael
Mast cells: innate attractors recruiting protective CD8 T cells to sites of cytomegalovirus infection
2015; 204 (3): 327-334

Raesch Simon Sebastian, Tenzer Stefan, Storck Wiebke, Rurainski Alexander, Selzer Dominik, Ruge Christian Arnold, Perez-Gil Jesus, Schaefer Ulrich Friedrich, Lehr Claus-Michael
Autoren der Einrichtung: Tenzer Stefan, Storck Wiebke
Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition
2015; 9 (12): 11872-11885

Ring Sabine, Pushkarevskaya Anna, Schild Hansjoerg, Probst Hans Christian, Jendrossek Verena, Wirsdoerfer Florian, Ledent Catherine, Robson Simon Christopher, Enk Alexander H., Mahnke Karsten
Autoren der Einrichtung: Schild Hansjoerg, Probst Hans Christian
Regulatory T Cell-Derived Adenosine Induces Dendritic Cell Migration through the Epac-Rap1 Pathway
2015; 194 (8): 3735-3744

Ritz Sandra, Schoettler Susanne, Kotman Niklas, Baier Grit, Musyanovych Anna, Kuharev Joerg, Landfester Katharina, Schild Hansjoerg, Jahn Olaf, Tenzer Stefan, Mailaender Volker
Autoren der Einrichtung: Kuharev Joerg, Schild Hansjoerg, Tenzer Stefan
Protein Corona of Nanoparticles: Distinct Proteins Regulate the Cellular Uptake
2015; 16 (4): 1311-1321

Schrick K., Bollmann F., Art J., Henke J., Besche V, Bros M., Li H., Siuda D., Handler N., Bauer F., Erker T., Behnke F., Moench B., Haerdle L., Hoffmann M., Chen C-Y, Foerstermann U., Dirsch V. M., Werz O., Kleinert H., Pautz A.
Autoren der Einrichtung: Hoffmann M.
Resveratrol regulates gene expression of pro-inflammatory mediators by enhancing the RNA-binding activity of KSRP
2015; 388: S28-S28

Seifermann M., Ulges A., Klingler P., Bopp T., Epe B.
Autoren der Einrichtung: Ulges A., Bopp T.
Deficiency in the DNA repair glycosylase OGG1 in mice results in decreased expression of TNFalpha
2015; 388: S75-S75

Selevsek Nathalie, Chang Ching-Yun, Gillet Ludovic C., Navarro Pedro, Bernhardt Oliver M., Reiter Lukas, Cheng Lin-Yang, Vitek Olga, Aebersold Ruedi
Autoren der Einrichtung: Navarro Pedro
Reproducible and Consistent Quantification of the Saccharomyces cerevisiae Proteome by SWATH-mass spectrometry
2015; 14 (3): 739-749

Stein Pamela, Gogoll Karsten, Peters Tanja, Denny Mark, Tenzer Stefan, Stevanovic Stefan, Schild Hansjoerg, Theobald Matthias, Langguth Peter, Radsak Markus
Autoren der Einrichtung: Tenzer Stefan, Schild Hansjoerg
Transcutaneous Immunization with a Solid Nanoscopic Imiquimod Suspension Enhances Tumor Rejection
2015; 126 (23):

Twelkmeyer T., Tenzer S., von Stebut E.
Autoren der Einrichtung: Tenzer S.
Isolation of parasitophorous vacuoles from L. major-infected phagocytes
2015; 24 (3): E27-E27

Ulges Alexander, Klein Matthias, Reuter Sebastian, Gerlitzki Bastian, Hoffmann Markus, Grebe Nadine, Staudt Valerie, Stergiou Natascha, Bohn Toszka, Bruehl Till-Julius, Muth Sabine, Yurugi Hajime, Rajalingam Krishnaraj, Bellinghausen Iris, Tuettenberg Andrea, Hahn Susanne, Reissig Sonja, Haben Irma, Zipp Frauke, Waisman Ari, Probst Hans-Christian, Beilhack Andreas, Buchou Thierry, Filhol-Cochet Odile, Boldyreff Brigitte, Breloer Minka, Jonuleit Helmut, Schild Hansjoerg, Schmitt Edgar, Bopp Tobias
Autoren der Einrichtung: Ulges Alexander, Klein Matthias, Gerlitzki Bastian, Hoffmann Markus, Grebe Nadine, Staudt Valerie, Stergiou Natascha, Bohn Toszka, Bruehl Till-Julius, Muth Sabine, Yurugi Hajime, Rajalingam Krishnaraj, Probst Hans-Christian, Schild Hansjoerg, Schmitt Edgar, Bopp Tobias
Protein kinase CK2 enables regulatory T cells to suppress excessive T(H)2 responses in vivo
2015; 16 (3): 267-U227

Umansky J, Weber M, Schild H, Radsak MP, Stein P
Autoren der Einrichtung: Weber M, Schild H, Stein P
Combined immunotherapy against cancer: Limited efficacy of transcutaneous immunization and low-dose Cyclophosphamide
2015; 3: 1-9

Wagner Miriam I., Mai Charlotte, Schmitt Edgar, Mahnke Karsten, Meuer Stefan, Eckstein Volker, Ho Anthony D., Schaier Matthias, Zeier Martin, Spratte Julia, Fluhr Herbert, Steinborn Andrea
Autoren der Einrichtung: Schmitt Edgar
The role of recent thymic emigrant-regulatory T-cell (RTE-Treg) differentiation during pregnancy
2015; 93 (10): 858-867

Weng Shih-Yen, Wang Xiaoyu, Kim Yong Ook, Kaps Leonard, Tang Yilang, Molokanova Olena, Crosby Jeff R., McCaleb Michael L., Frank Brombacher, Bopp Tobias, Schild Hans-Joerg, Waisman Ari, Schuppan Detlef
Autoren der Einrichtung: Bopp Tobias, Schild Hans-Joerg
IL-13R alpha 1 signaling and M2 macrophages but not Th2 T cells drive progression of CCL4-induce fibrosis
2015; 62: 874A-874A

Weng S. -Y., Wang X. -Y., Tang Y., Kim Y. O., Molokanova O., Brombacher F., Bopp T., Schild H. -J., Waisman A., Schuppan D.
Autoren der Einrichtung: Bopp T., Schild H. -J.
IL-4/IL-13 EXACERBATE LIVER FIBROSIS PROGRESSION THROUGH ALTERNATIVELY ACTIVATED MACROPHAGES
2015; 62: S474-S474

Various Scientific Activities

Prize

Dr. Alexander Ulges
Boehringer-Ingelheim-Preis 2015

Dr. Alexander Ulges
Otto-Westphal-Promotionspreis 2015 (DGfI)

Other

Dr. Inga Melzer
Selected as participant in the Edith Heischkel Mentoring Programme of the University Medical Centre Mainz

Univ.-Prof. Dr. Krishnaraj Rajalingam
Selected as new member of the Gutenberg Research College (GRC)