Institute of Immunology

Facility Statistics

Research Projects

Development and testing of nanoparticles for inhibition of cAMP-mediated immunosuppression of malignant melanoma

CRC-TR-128 Project B04: T helper cell balance in chronic neuroinflammation – influence by antigen-presenting cells

Functional clustering of T cell and other immune cell sub-phenotypes across plasticity and individualities of immune-mediated diseases

ICER-steered transcriptional regulation in cAMP-driven immune evasion mechanisms of malignant melanoma

Integrierte Multi-Omics Analyse zur Aufklärung von Tumor-Pathomechanismen

Polymer-mediated tumor immunotherapy by in situ activation of antigen-presenting cells

Suppressive mechanisms of regulatory T cells controlling CD8+ T cells in steady state, cancer and chronic infection

Transcutaneous immunization: Mechanisms of intracellular networks of the skin (TRR156, A05)

Gutenberg Forschungskolleg (GFK) Fellowship

Heisenberg (DFG)

Oncogenic MAPK signaling in regulating anti tumor immunity

Functional analysis of skin subsets of dendritic cells in T cell priming and tolerance using inducible transgenic mice that allow subset specific antigen expression (TRR156, B02)

Identifizierung und immuntherapeutische Charakterisierung Tumorassoziierter Antigene und Neoantigene in genetischen und karzinogen-induzierten Melanom Tumormodellen

Multifunctional nanoscale peptide/glykopeptide conjugates as synthetic vaccines for anti-tumor immunotherapy

Wheat sensitivity: Impact of wheat varieties and growing conditions on innate immunity

Integrierte OMICs und Bioinformatik Plattform

Proteine auf Nanocarriern: vom Stealth Effekt zu einem gezielten Targeting in vivo

Rapid evolutionary adaptation: Potential and contraints

Thiol switches controlled by the glutathione-S-transferase GDAP1

Weizensensitivität: Einfluss von Weizensorten und Anbaubedingungen auf die angeborene Immunität (DFG)

Bedeutung von Serum in der GVHD-Entstehung

Publications

Ainooson George K., Gourain Victor, Stassen Michael, Cato Andrew C. B.
Autoren der Einrichtung: Stassen Michael
Transcriptomic data on the role of PEST-domain-enriched tyrosine phosphatase in the regulation of antigen-mediated activation and antiallergic action of glucocorticoids in mast cells
2018; 20: 1177-1183

Alflen Astrid, Pruefer Steve, Ebner Katharina, Reuter Sebastian, Lopez Pamela Aranda, Scharrer Inge, Banno Fumiaki, Stassen Michael, Schild Hansjoerg, Jurk Kerstin, Bosmann Markus, Beckert Hendrik, Radsak Markus P.
Autoren der Einrichtung: Pruefer Steve, Stassen Michael, Schild Hansjoerg
ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis (vol 7, 7184, 2017)
2018; 8:

Arens Katharina, Filippis Christodoulos, Kleinfelder Helen, Goetzee Arthur, Reichmann Gabriele, Crauwels Peter, Waibler Zoe, Bagola Katrin, van Zandbergen Ger
Autoren der Einrichtung: van Zandbergen Ger
Anti-Tumor Necrosis Factor a Therapeutics Differentially Affect Leishmania Infection of Human Macrophages
2018; 9:

Bidmon Nicole, Kind Sonja, Welters Marij J. P., Joseph-Pietras Deborah, Laske Karoline, Maurer Dominik, Hadrup Sine Reker, Schreibelt Gerty, Rae Richard, Sahin Ugur, Gouttefangeas Cecile, Britten Cedrik M., van der Burg Sjoerd H.
Autoren der Einrichtung: Sahin Ugur
Development of an RNA-based kit for easy generation of TCR-engineered lymphocytes to control T-cell assay performance
2018; 458: 74-82

Bohn Toszka, Rapp Steffen, Luther Natascha, Klein Matthias, Bruehl Till-Julius, Kojima Nobuhiko, Lopez Pamela Aranda, Hahlbrock Jennifer, Muth Sabine, Endo Shogo, Pektor Stefanie, Brand Almut, Renner Kathrin, Popp Vanessa, Gerlach Katharina, Vogel Dennis, Lueckel Christina, Arnold-Schild Danielle, Pouyssegur Jacques, Kreutz Marina, Huber Magdalena, Koenig Jochem, Weigmann Benno, Probst Hans-Christian, von Stebut Esther, Becker Christian, Schild Hansjoerg, Schmitt Edgar, Bopp Tobias
Autoren der Einrichtung: Bohn Toszka, Klein Matthias, Bruehl Till-Julius, Hahlbrock Jennifer, Muth Sabine, Lueckel Christina, Arnold-Schild Danielle, Probst Hans-Christian, Schild Hansjoerg, Schmitt Edgar, Bopp Tobias
Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
2018; 19 (12): 1319-+

Bopp T., Schild H.
Autoren der Einrichtung: Bopp T., Schild H.
Immunological foundations of modern (tumor) immunotherapy
2018; 39 (6): 492-497

Buehler Ulrike, Schulenburg Katharina, Yurugi Hajime, Solman Maja, Abankwa Daniel, Ulges Alexander, Tenzer Stefan, Bopp Tobias, Thiede Bernd, Zipp Frauke, Rajalingam Krishnaraj
Autoren der Einrichtung: Ulges Alexander, Tenzer Stefan, Bopp Tobias
Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity
2018; 37 (16):

Dobelmann J., Alflen A., Lopez Aranda P., Zevallos V., Schuppan D., Radsak M.
Autoren der Einrichtung: Dobelmann J., Alflen A., Lopez Aranda P., Radsak M.
The influence of wheat amylase-trypsin inhibitors (ATI) on effector functions of neutrophil granulocytes
2018; 41: 103-103

Fiore Alessandra, Ugel Stefano, De Sanctis Francesco, Sandri Sara, Fracasso Giulio, Trovato Rosalinda, Sartoris Silvia, Solito Samantha, Mandruzzato Susanna, Vascotto Fulvia, Hippen Keli L., Mondanelli Giada, Grohmann Ursula, Piro Geny, Carbone Carmine, Melisi Davide, Lawlor Rita T., Scarpa Aldo, Lamolinara Alessia, Iezzi Manuela, Fassan Matteo, Bicciato Silvio, Blazar Bruce R., Sahin Ugur, Murray Peter J., Bronte Vincenzo
Autoren der Einrichtung: Sahin Ugur
Induction of immunosuppressive functions and NF-kappa B by FLIP in monocytes
2018; 9:

Foerster Friedrich, Hess Moritz, Gerhold-Ay Aslihan, Marquardt Jens Uwe, Becker Diana, Galle Peter Robert, Schuppan Detlef, Binder Harald, Bockamp Ernesto
Autoren der Einrichtung: Bockamp Ernesto
The immune contexture of hepatocellular carcinoma predicts clinical outcome
2018; 8:

Glaffig Markus, Stergiou Natascha, Hartmann Sebastian, Schmitt Edgar, Kunz Horst
Autoren der Einrichtung: Stergiou Natascha, Schmitt Edgar
A Synthetic MUC1 Anticancer Vaccine Containing Mannose Ligands for Targeting Macrophages and Dendritic Cells
2018; 13 (1): 25-29

Hoch-Kraft Peter, White Robin, Tenzer Stefan, Kraemer-Albers Eva-Maria, Trotter Jacqueline, Gonsior Constantin
Autoren der Einrichtung: Tenzer Stefan
Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes
2018; 131 (9):

Imre Gergely, Rajalingam Krishnaraj
Autoren der Einrichtung: Rajalingam Krishnaraj
Apoptosis inhibitor 5: Role in the inhibition of caspase-2
2018; 17 (4): 397-398

Karthik Isai Pratha, Desai Pavitra, Sukumar Sudarkodi, Dimitrijevic Aleksandra, Rajalingam Krishnaraj, Mahalingam Sundarasamy
Autoren der Einrichtung: Dimitrijevic Aleksandra, Rajalingam Krishnaraj
E4BP4/NFIL3 modulates the epigenetically repressed RAS effector RASSF8 function through histone methyltransferases
2018; 293 (15): 5624-5635

Kehl Tim, Schneider Lara, Kattler Kathrin, Stoeckel Daniel, Wegert Jenny, Gerstner Nico, Ludwig Nicole, Distler Ute, Schick Markus, Keller Ulrich, Tenzer Stefan, Gessler Manfred, Walter Joern, Keller Andreas, Graf Norbert, Meese Eckart, Lenhof Hans-Peter
Autoren der Einrichtung: Distler Ute, Tenzer Stefan
REGGAE: a novel approach for the identification of key transcriptional regulators
2018; 34 (20): 3503-3510

Kroeller-Schoen Swenja, Daiber Andreas, Steven Sebastian, Oelze Matthias, Frenis Katie, Kalinovic Sanela, Heimann Axel, Schmidt Frank P., Pinto Antonio, Kvandova Miroslava, Vujacic-Mirski Ksenija, Filippou Konstantina, Dudek Markus, Bosmann Markus, Klein Matthias, Bopp Tobias, Hahad Omar, Wild Philipp S., Frauenknecht Katrin, Methner Axel, Schmidt Erwin R., Rapp Steffen, Mollnau Hanke, Muenzel Thomas
Autoren der Einrichtung: Klein Matthias, Bopp Tobias
Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation
2018; 39 (38): 3528-+

Lacher Sonja M., Thurm Christoph, Distler Ute, Mohebiany Alma N., Israel Nicole, Kitic Maja, Ebering Anna, Tang Yilang, Klein Matthias, Wabnitz Guido H., Wanke Florian, Samstag Yvonne, Bopp Tobias, Kurschus Florian C., Simeoni Luca, Tenzer Stefan, Waisman Ari
Autoren der Einrichtung: Distler Ute, Klein Matthias, Bopp Tobias, Tenzer Stefan
NF-kappa B inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling
2018; 94: 110-121

Lill Jennie R., van Veelen Peter A., Tenzer Stefan, Admon Arie, Caron Etienne, Elias Joshua E., Heck Albert J. R., Marcilla Miguel, Marino Fabio, Mueller Markus, Peters Bjoern, Purcell Anthony, Sette Alessandro, Sturm Theo, Ternette Nicola, Vizcaino Juan Antonio, Bassani-Sternberg Michal
Autoren der Einrichtung: Tenzer Stefan
Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE)
2018; 18 (12):

Melchior F., Muth S., Hain T., Kamenjarin N., Buendgen G., Klein M., Clausen B. E., Mahnke K., Schild H., Probst H. C.
Autoren der Einrichtung: Melchior F., Muth S., Hain T., Kamenjarin N., Buendgen G., Klein M., Schild H., Probst H. C.
Functional analysis of dermal DC subpopulations
2018; 48: 152-153

Ogorodnikov Anton, Levin Michal, Tattikota Surendra, Tokalov Sergey, Hoque Mainul, Scherzinger Denise, Marini Federico, Poetsch Ansgar, Binder Harald, Macher-Goeppinger Stephan, Probst Hans Christian, Tian Bin, Schaefer Michael, Lackner Karl J., Westermann Frank, Danckwardt Sven
Autoren der Einrichtung: Probst Hans Christian
Transcriptome 3 ' end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma
2018; 9:

Ruder Barbara, Murtadak Vinay, Stuerzl Michael, Wirtz Stefan, Distler Ute, Tenzer Stefan, Mahapatro Mousumi, Greten Florian R., Hu Yinling, Neurath Markus F., Cesarman Ethel, Ballon Gianna, Guenther Claudia, Becker Christoph
Autoren der Einrichtung: Distler Ute, Tenzer Stefan
Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells
2018; 11 (6): 1621-1629

Sahin Ugur
Autoren der Einrichtung: Sahin Ugur
Studying Tumor-ReacTive T Cells: A Personalized Organoid Model
2018; 23 (3): 318-319

Schille Stefan, Crauwels Peter, Bohn Rebecca, Bagola Katrin, Walther Paul, van Zandbergen Ger
Autoren der Einrichtung: van Zandbergen Ger
LC3-associated phagocytosis in microbial pathogenesis
2018; 308 (1): 228-236

Shen Limei, Tenzer Stefan, Hess Moritz, Distler Ute, Tubbe Ingrid, Montermann Evelyn, Schimmer Simone, Dittmer Ulf, Grabbe Stephan, Bros Matthias
Autoren der Einrichtung: Tenzer Stefan, Distler Ute
Friend virus limits adaptive cellular immune responses by imprinting a maturation-resistant and T helper type 2-biased immunophenotype in dendritic cells
2018; 13 (2):

Shen Limei, Tenzer Stefan, Storck Wiebke, Hobernik Dominika, Raker Verena Katherina, Fischer Karl, Decker Sandra, Dzionek Andrzej, Krauthaeuser Susanne, Diken Mustafa, Nikolaev Alexej, Maxeiner Joachim, Schuster Petra, Kappel Cinja, Verschoor Admar, Schild Hansjoerg, Grabbe Stephan, Bros Matthias
Autoren der Einrichtung: Tenzer Stefan, Storck Wiebke, Schild Hansjoerg
Protein corona-mediated targeting of nanocarriers to B cells allows redirection of allergic immune responses
2018; 142 (5): 1558-1570

Stergiou N., Nagel J., Pektor S., Miederer M., Kunz H., Roesch F., Schmitt E.
Autoren der Einrichtung: Stergiou N., Schmitt E.
Diagnostic evaluation of a novel Zr-89-labeled monoclonal antibody against tumor-associated mucin 1 in a preclinical breast cancer model
2018; 45: S119-S119

Stork L., Brueck W., von Gottberg P., Pulkowski U., Kirsten F., Glatzel M., Rauer S., Scheibe F., Radbruch H., Hammer E., Stuerner K. H., Kaulen B., Hoffmann F., Brock S., Pawlitzki M., Bopp T., Metz I.
Autoren der Einrichtung: Bopp T.
Severe encephalitis and meningoencephalitis with systemic symptoms after daclizumab therapy for multiple sclerosis.
2018; 24: 36-37

Strassburger David, Stergiou Natascha, Urschbach Moritz, Yurugi Hajime, Spitzer Daniel, Schollmeyer Dieter, Schmitt Edgar, Besenius Pol
Autoren der Einrichtung: Stergiou Natascha, Schmitt Edgar
Mannose-Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen-Presenting Cells
2018; 19 (9): 912-916

Strassburger David, Stergiou Natascha, Kunz Horst, Schmitt Edgar, Besenius Pol
Autoren der Einrichtung: Stergiou Natascha, Schmitt Edgar
Multicomponent supramolecular polymers as a platform for the design of modular glycoconjugate vaccines
2018; 256:

Strassburger David, Stergiou Natascha, Schmitt Edgar, Besenius Pol
Autoren der Einrichtung: Stergiou Natascha, Schmitt Edgar
Self-Assembling Peptides as a Platform for Supramolecular Antitumor Vaccines
2018; 24: S134-S134

Strassburger David, Glaffig Markus, Stergiou Natascha, Bialas Sabrina, Besenius Pol, Schmitt Edgar, Kunz Horst
Autoren der Einrichtung: Stergiou Natascha, Schmitt Edgar
Synthetic MUC1 Antitumor Vaccine with Incorporated 2,3-Sialyl-T Carbohydrate Antigen Inducing Strong Immune Responses with Isotype Specificity
2018; 19 (11): 1142-1146

Thaher Osamah, Wolf Christina, Dey Partha Narayan, Pouya Alireza, Wuellner Verena, Tenzer Stefan, Methner Axel
Autoren der Einrichtung: Tenzer Stefan
The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration
2018; 117: 167-173

Thalman Carine, Horta Guilherme, Qiao Lianyong, Endle Heiko, Tegeder Irmgard, Cheng Hong, Laube Gregor, Sigrudsson Torfi, Hauser Maria Jelena, Tenzer Stefan, Distler Ute, Aoki Junken, Morris Andrew J., Geisslinger Gerd, Roeper Jochen, Kirischuk Sergei, Luhmann Heiko J., Radyushkin Konstantin, Nitsch Robert, Vogt Johannes
Autoren der Einrichtung: Tenzer Stefan, Distler Ute
( Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders)
2018; 23 (8): 1699-1710

Tuereci Oezlem, Loewer Martin, Schroers Barbara, Lang Maren, Tadmor Arbel, Sahin Ugur
Autoren der Einrichtung: Sahin Ugur
Challenges towards the realization of individualized cancer vaccines
2018; 2 (8): 566-569

von Stebut Esther, Tenzer Stefan
Autoren der Einrichtung: Tenzer Stefan
Cutaneous leishmaniasis: Distinct functions of dendritic cells and macrophages in the interaction of the host immune system with Leishmania major
2018; 308 (1): 206-214

Weng Shih-Yen, Wang Xiaoyu, Vijayan Santosh, Tang Yilang, Kim Yong Ook, Padberg Kornelius, Regen Tommy, Molokanova Olena, Chena Tao, Bopp Tobias, Schild Hansjoerg, Brombacher Frank, Crosby Jeff R., McCaleb Michael L., Waisman Ari, Bockamp Ernesto, Schuppan Detlef
Autoren der Einrichtung: Bopp Tobias, Schild Hansjoerg
IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal
2018; 29: 92-103

Zimmermann Christine, Buescher Nicole, Krauter Steffi, Kraemer Nadine, Wolfrum Uwe, Sehn Elisabeth, Tenzer Stefan, Plachter Bodo
Autoren der Einrichtung: Tenzer Stefan
The Abundant Tegument Protein pUL25 of Human Cytomegalovirus Prevents Proteasomal Degradation of pUL26 and Supports Its Suppression of ISGylation
2018; 92 (24):