Institute of Immunology

Facility Statistics

Research Projects

Development and testing of nanoparticles for inhibition of cAMP-mediated immunosuppression of malignant melanoma

CRC-TR-128 Project B04: T helper cell balance in chronic neuroinflammation – influence by antigen-presenting cells

Deciphering the role of the IRF4 interactome in differentiating regulatory and T helper 17 cells in health and autoimmune disease

Functional clustering of T cell and other immune cell sub-phenotypes across plasticity and individualities of immune-mediated diseases

Funktionelle Relevanz von CD18 und regulatorischen T-Zellen in der Haut

ICER-steered transcriptional regulation in cAMP-driven immune evasion mechanisms of malignant melanoma

Polymer-mediated tumor immunotherapy by in situ activation of antigen-presenting cells

Subpopulationen dendritischer Zellen der Haut und äußere Einflüsse in der Induktion und Modulation von T-Zell Antworten in der Haut

Suppressive mechanisms of regulatory T cells controlling CD8+ T cells in steady state, cancer and chronic infection

Transcutaneous immunization: Mechanisms of intracellular networks of the skin (TRR156, A05)

Gutenberg Forschungskolleg (GFK) Fellowship

Heisenberg (DFG)

Oncogenic MAPK signaling in regulating anti tumor immunity

Functional analysis of skin subsets of dendritic cells in T cell priming and tolerance using inducible transgenic mice that allow subset specific antigen expression (TRR156, B02)

Identifizierung und immuntherapeutische Charakterisierung Tumorassoziierter Antigene und Neoantigene in genetischen und karzinogen-induzierten Melanom Tumormodellen

Multifunctional nanoscale peptide/glykopeptide conjugates as synthetic vaccines for anti-tumor immunotherapy

Wheat sensitivity: Impact of wheat varieties and growing conditions on innate immunity

Integrierte OMICs und Bioinformatik Plattform

Proteine auf Nanocarriern: vom Stealth Effekt zu einem gezielten Targeting in vivo

Rapid evolutionary adaptation: Potential and contraints

Thiol switches controlled by the glutathione-S-transferase GDAP1

Weizensensitivität: Einfluss von Weizensorten und Anbaubedingungen auf die angeborene Immunität (DFG)

Bedeutung von Serum in der GVHD-Entstehung

Publications

Bialojan Ariane, Sohl Julian, Rausch Johanna, Aranda Lopez Pamela, Denny Mark, Langguth Peter, Hartmann Ann-Kathrin, Yagita Hideo, Probst Hans Christian, Schild Hansjoerg, Radsak Markus P.
Autoren der Einrichtung: Probst Hans Christian, Schild Hansjoerg
Transcutaneous immunization with CD40 ligation boosts cytotoxic T lymphocyte mediated antitumor immunity independent of CD4 helper cells in mice
2019; 49 (11): 2083-2094

Bohn T., Rapp S., Pektor S., Gerlach K., Weigmann B., Lueckel C., Truong N., von Stebut E., Schild H., Bopp T.
Autoren der Einrichtung: Bohn T., Lueckel C., Truong N., Schild H., Bopp T.
Tumor immunoevasion by high glycolytic tumors through an acidosis-dependent induction of noninflammatory tumor-associated macrophages
2019; 49: 36-36

Bohnert Stefan, Heck Larissa, Gruber Christoph, Neumann Hendrik, Distler Ute, Tenzer Stefan, Yemelin Alexander, Thines Eckhard, Jacob Stefan
Autoren der Einrichtung: Distler Ute, Tenzer Stefan
Fungicide resistance toward fludioxonil conferred by overexpression of the phosphatase gene MoPTP2 in Magnaporthe oryzae
2019; 111 (3): 662-677

Crauwels Peter, Bank Elena, Walber Bianca, Wenzel Ulf Alexander, Agerberth Birgitta, Chanyalew Menberework, Abebe Markos, Koenig Renate, Ritter Uwe, Reiling Norbert, van Zandbergen Ger
Autoren der Einrichtung: van Zandbergen Ger
Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages
2019; 10:

Dietz L., Qureischi M., Xiao Y., Vallabhapurapu S. D., Klein-Hessling S., Klein M., Konig A., Serfling E., Mottok A., Bopp T., Rosenwald A., Buttmann M., Berberich I, Beilhack A., Berberich-Siebelt F.
Autoren der Einrichtung: Klein M., Bopp T.
Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity
2019; 49: 685-685

Distler Ute, Lacki Mateusz Krzysztof, Schumann Sven, Wanninger Markus, Tenzer Stefan
Autoren der Einrichtung: Distler Ute, Lacki Mateusz Krzysztof, Tenzer Stefan
Enhancing Sensitivity of Microflow-Based Bottom-Up Proteomics through Postcolumn Solvent Addition
2019; 91 (12): 7510-7515

Finger Stefanie, Knorr Maike, Molitor Michael, Schueler Rebecca, Garlapati Venkata, Waisman Ari, Brandt Moritz, Muenzel Thomas, Bopp Tobias, Kossmann Sabine, Karbach Susanne, Wenzel Philip
Autoren der Einrichtung: Bopp Tobias
A sequential interferon gamma directed chemotactic cellular immune response determines survival and cardiac function post-myocardial infarction
2019; 115 (13): 1907-1917

Garg Archit, Orru Roberto, Ye Weixiang, Distler Ute, Chojnacki Jeremy E., Koehn Maja, Tenzer Stefan, Soennichsen Carsten, Wolf Eva
Autoren der Einrichtung: Distler Ute, Tenzer Stefan
Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein
2019; 294 (45): 16604-16619

Hahlbrock J., Arnold-Schild D., Stickdorn J., Ziss T., Bros M., Grabbe S., Nuhn L., Schild H.
Autoren der Einrichtung: Hahlbrock J., Arnold-Schild D., Schild H.
Polymer-mediated tumour immunotherapy by in situ activation of antigen presenting cells
2019; 49: 72-72

Hain Tobias, Melchior Felix, Kamenjarin Nadine, Muth Sabine, Weslati Hela, Clausen Bjoern E., Mahnke Karsten, Silva-Vilches Cinthia, Schuetze Kristian, Sohl Julian, Radsak Markus P., Buendgen Georg, Bopp Tobias, Danckwardt Sven, Schild Hansjoerg, Probst Hans Christian
Autoren der Einrichtung: Hain Tobias, Melchior Felix, Kamenjarin Nadine, Muth Sabine, Weslati Hela, Schuetze Kristian, Sohl Julian, Radsak Markus P., Buendgen Georg, Bopp Tobias, Schild Hansjoerg, Probst Hans Christian
Dermal CD207-Negative Migratory Dendritic Cells Are Fully Competent to Prime Protective, Skin Homing Cytotoxic T-Lymphocyte Responses
2019; 139 (2): 422-429

Haub Jessica, Roehrig Nadine, Uhrin Pavel, Schabbauer Gernot, Eulberg Dirk, Melchior Felix, Shahneh Fatemeh, Probst Hans Christian, Becker Christian, Steinbrink Kerstin, Raker Verena K.
Autoren der Einrichtung: Melchior Felix, Probst Hans Christian
Intervention of Inflammatory Monocyte Activity Limits Dermal Fibrosis
2019; 139 (10): 2144-2153

Haupeltshofer Steffen, Leichsenring Teresa, Berg Sarah, Pedreiturria Xiomara, Joachim Stephanie C., Tischoff Iris, Otte Jan-Michel, Bopp Tobias, Fantini Massimo C., Esser Charlotte, Willbold Dieter, Gold Ralf, Faissner Simon, Kleiter Ingo
Autoren der Einrichtung: Bopp Tobias
Smad7 in intestinal CD4(+) T cells determines autoimmunity in a spontaneous model of multiple sclerosis
2019; 116 (51): 25860-25869

Kehl Tim, Schneider Lara, Kattler Kathrin, Stoeckel Daniel, Wegert Jenny, Gerstner Nico, Ludwig Nicole, Distler Ute, Tenzer Stefan, Gessler Manfred, Walter Joern, Keller Andreas, Graf Norbert, Meese Eckart, Lenhof Hans-Peter
Autoren der Einrichtung: Distler Ute, Tenzer Stefan
The role of TCF3 as potential master regulator in blastemal Wilms tumors
2019; 144 (6): 1432-1443

Klasen Benedikt, Stergiou Natascha, Moon Euy Sung, Schmitt Edgar, Roesch Frank
Autoren der Einrichtung: Stergiou Natascha, Schmitt Edgar
Radiolabeling and in vitro evaluation of a TA-MUC1 specific monoclonal antibody and its corresponding single chain fragment with zirconium-89, scandium-44, and lutetium-177: Promising tools for diagnosis and therapy of breast cancer
2019; 62: S517-S518

Klemm P., Fragoulis A., Wruck C., Schippers A., Wagner N., Bopp T., Tenbrock K., Ohl K.
Autoren der Einrichtung: Bopp T.
Foxp3 specific activation of Nrf2 results in loss of immune tolerance
2019; 49: 284-285

Kotal Jan, Stergiou Natascha, Busa Michal, Chlastakova Adela, Berankova Zuzana, Rezacova Pavlina, Langhansova Helena, Schwarz Alexandra, Calvo Eric, Kopecky Jan, Mares Michael, Schmitt Edgar, Chmelar Jindrich, Kotsyfakis Michail
Autoren der Einrichtung: Stergiou Natascha, Schmitt Edgar
The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin
2019; 76 (10): 2003-2013

Kraemer Tobias J., Hack Nathalia, Bruehl Till J., Menzel Lutz, Hummel Regina, Griemert Eva-Verena, Klein Matthias, Thal Serge C., Bopp Tobias, Schaefer Michael K. E.
Autoren der Einrichtung: Bruehl Till J., Klein Matthias, Bopp Tobias
Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-gamma gene expression in acute experimental traumatic brain injury
2019; 16 (1):

Kraemer Tobias J., Hack Nathalia, Bruehl Till J., Menzel Lutz, Hummel Regina, Griemert Eva-Verena, Klein Matthias, Thal Serge C., Bopp Tobias, Schaefer Michael K. E.
Autoren der Einrichtung: Bruehl Till J., Klein Matthias, Bopp Tobias
Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-gamma gene expression in acute experimental traumatic brain injury (vol 16, pg 163, 2019)
2019; 16 (1):

Lueckel C., Picard F., Raifer H., Carrascosa L. Campos, Klein M., Moos S., Bonetti L., Grusdat M., Kurschus F., Brenner D., Kallies A., Bittner S., Tackenberg B., Bopp T., Huber M.
Autoren der Einrichtung: Lueckel C., Klein M., Bopp T.
Dimethyl fumarate targets IL-17-producing CD8(+) T cells to limit autoimmunity
2019; 49: 220-220

Lueckel Christina, Picard Felix, Raifer Hartmann, Carrascosa Lucia Campos, Guralnik Anna, Zhang Yajuan, Klein Matthias, Bittner Stefan, Steffen Falk, Moos Sonja, Marini Federico, Gloury Renee, Kurschus Florian C., Chao Ying-Yin, Bertrams Wilhelm, Sexl Veronika, Schmeck Bernd, Bonetti Lynn, Grusdat Melanie, Lohoff Michael, Zielinski Christina E., Zipp Frauke, Kallies Axel, Brenner Dirk, Berger Michael, Bopp Tobias, Tackenberg Bjoern, Huber Magdalena
Autoren der Einrichtung: Lueckel Christina, Klein Matthias, Bopp Tobias
IL-17(+) CD8(+) T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis
2019; 10:

Makhoul Stephanie, Trabold Katharina, Gambaryan Stepan, Tenzer Stefan, Pillitteri Daniele, Walter Ulrich, Jurk Kerstin
Autoren der Einrichtung: Tenzer Stefan
cAMP- and cGMP-elevating agents inhibit GPIb alpha-mediated aggregation but not GPIb alpha-stimulated Syk activation in human platelets
2019; 17 (1):

Moritz Christian P., Muehlhaus Timo, Tenzer Stefan, Schulenborg Thomas, Friauf Eckhard
Autoren der Einrichtung: Tenzer Stefan
Poor transcript-protein correlation in the brain: negatively correlating gene products reveal neuronal polarity as a potential cause
2019; 149 (5): 582-604

Rauschenberger Tabea, Schmitt Viola, Azeem Muhammad, Klein-Hessling Stefan, Murti Krisna, Graen Franziska, Goebeler Matthias, Kerstan Andreas, Klein Matthias, Bopp Tobias, Serfling Edgar, Muhammad Khalid
Autoren der Einrichtung: Klein Matthias, Bopp Tobias
T Cells Control Chemokine Secretion by Keratinocytes
2019; 10:

Regen T., Isaac S., Amorim A. De Oliveira, Nunez N. Gonzalo, Hauptmann J., Shanmugavadivu A., Klein M., Sankowski R., Mufazalov I. A., Yogev N., Huppert J., Wanke F., Schelmbauer C., Grill A., Galvez E. J. C., Nikolaev A., Blanfeld M., Mueller W., Prinz I., Strowig T., Reinhardt C., Prinz M., Bopp T., Becher B., Ubeda C., Waisman A.
Autoren der Einrichtung: Klein M., Bopp T.
IL-17 controls CNS autoimmunity through the intestinal microbiome
2019; 25: 920-920

Renner Kathrin, Bruss Christina, Schnell Annette, Koehl Gudrun, Becker Holger M., Fante Matthias, Menevse Ayse-Nur, Kauer Nathalie, Blazquez Raquel, Hacker Lisa, Decking Sonja-Maria, Bohn Toszka, Faerber Stephanie, Evert Katja, Aigle Lisa, Amslinger Sabine, Landa Maria, Krijgsman Oscar, Rozeman Elisa A., Brummer Christina, Siska Peter J., Singer Katrin, Pektor Stefanie, Miederer Matthias, Peter Katrin, Gottfried Eva, Herr Wolfgang, Marchiq Ibtisam, Pouyssegur Jacques, Roush William R., Ong SuFey, Warren Sarah, Pukrop Tobias, Beckhove Philipp, Lang Sven A., Bopp Tobias, Blank Christian U., Cleveland John L., Oefner Peter J., Dettmer Katja, Selby Mark, Kreutz Marina
Autoren der Einrichtung: Bohn Toszka, Bopp Tobias
Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy
2019; 29 (1): 135-+

Ries Frederic, Alflen Astrid, Lopez Pamela Aranda, Beckert Hendrik, Theobald Matthias, Schild Hansjoerg, Teschner Daniel, Radsak Markus Philipp
Autoren der Einrichtung: Schild Hansjoerg
Antifungal Drugs Influence Neutrophil Effector Functions
2019; 63 (6):

Schille S., Bohn R., Thomas M., Reiling N., Tenzer S., Bagola K., van Zandbergen G.
Autoren der Einrichtung: Tenzer S., van Zandbergen G.
Complement Receptor 3 internalizes apoptotic Leishmania promastigotes and triggers LC3 associated phagocytosis in primary human macrophages
2019; 49: 251-252

Silva-Vilches Cinthia, Ring Sabine, Schrader Juergen, Clausen Bjoern E., Probst Hans-Christian, Melchior Felix, Schild Hansjoerg, Enk Alexander, Mahnke Karsten
Autoren der Einrichtung: Probst Hans-Christian, Melchior Felix, Schild Hansjoerg
Production of Extracellular Adenosine by CD73(+) Dendritic Cells Is Crucial for Induction of Tolerance in Contact Hypersensitivity Reactions
2019; 139 (3): 541-551

Stassen Michael, Hartmann Ann-Kathrin, Delgado Sharon Jimenez, Dehmel Susann, Braun Armin
Autoren der Einrichtung: Stassen Michael, Hartmann Ann-Kathrin
Mast cells within cellular networks
2019; 144 (4): S46-S54

Stergiou Natascha, Nagel Johannes, Pektor Stefanie, Heimes Anne-Sophie, Jakel Jorg, Brenner Walburgis, Schmidt Marcus, Miederer Matthias, Kunz Horst, Roesch Frank, Schmitt Edgar
Autoren der Einrichtung: Stergiou Natascha, Schmitt Edgar
Evaluation of a novel monoclonal antibody against tumor-associated MUC1 for diagnosis and prognosis of breast cancer
2019; 16 (9): 1188-1198

Stergiou Natascha, Gaidzik Nikola, Heimes Anne-Sophie, Dietzen Sarah, Besenius Pol, Jaekel Joerg, Brenner Walburgis, Schmidt Marcus, Kunz Horst, Schmitt Edgar
Autoren der Einrichtung: Stergiou Natascha, Dietzen Sarah, Schmitt Edgar
Reduced Breast Tumor Growth after Immunization with a Tumor-Restricted MUC1 Glycopeptide Conjugated to Tetanus Toxoid
2019; 7 (1): 113-122

Stork Lidia, Brueck Wolfgang, von Gottberg Phillip, Pulkowski Ulrich, Kirsten Florian, Glatzel Markus, Rauer Sebastian, Scheibe Franziska, Radbruch Helena, Hammer Eckhard, Stuerner Klarissa H., Kaulen Barbara, Heesen Christoph, Hoffmann Frank, Brock Sebastian, Pawlitzki Marc, Bopp Tobias, Metz Imke
Autoren der Einrichtung: Bopp Tobias
Severe meningo-/encephalitis after daclizumab therapy for multiple sclerosis
2019; 25 (12): 1618-1632

Strassburger David, Stergiou Natascha, Schmitt Edgar, Besenius Pol
Autoren der Einrichtung: Stergiou Natascha, Schmitt Edgar
Multicomponent supramolecular polymers as a platform for the design of glycopeptide antitumor vaccines
2019; 257:

Truong-Andrievici N., Bohn T., Klein M., Hahlbrock J., Distler U., Tenzer S., Bopp T.
Autoren der Einrichtung: Truong-Andrievici N., Bohn T., Klein M., Hahlbrock J., Distler U., Tenzer S., Bopp T.
Omics-Analyses of B16 and MC38 tumors and their Tumor-associated macrophages (TAM)
2019; 49: 169-169

Visekruna Alexander, Hartmann Sabrina, Sillke Yasmina Rodriguez, Glauben Rainer, Fischer Florence, Raifer Hartmann, Mollenkopf Hans, Bertrams Wilhelm, Schmeck Bernd, Klein Matthias, Pagenstecher Axel, Lohoff Michael, Jacob Ralf, Pabst Oliver, Bland Paul William, Luu Maik, Romero Rossana, Siegmund Britta, Rajalingam Krishnaraj, Steinhoff Ulrich
Autoren der Einrichtung: Klein Matthias
Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells
2019; 129 (5): 1972-1983