Institut für Immunologie

Facility Statistics

Research Projects

Development and testing of nanoparticles for inhibition of cAMP-mediated immunosuppression of malignant melanoma

CRC-TR-128 Project B04: T helper cell balance in chronic neuroinflammation – influence by antigen-presenting cells

Deciphering the role of the IRF4 interactome in differentiating regulatory and T helper 17 cells in health and autoimmune disease

Functional clustering of T cell and other immune cell sub-phenotypes across plasticity and individualities of immune-mediated diseases

Funktionelle Relevanz von CD18 und regulatorischen T-Zellen in der Haut

ICER-steered transcriptional regulation in cAMP-driven immune evasion mechanisms of malignant melanoma

Polymer-mediated tumor immunotherapy by in situ activation of antigen-presenting cells

Subpopulationen dendritischer Zellen der Haut und äußere Einflüsse in der Induktion und Modulation von T-Zell Antworten in der Haut

Suppressive mechanisms of regulatory T cells controlling CD8+ T cells in steady state, cancer and chronic infection

Oncogenic MAPK signaling in regulating anti tumor immunity

Identifizierung und immuntherapeutische Charakterisierung Tumorassoziierter Antigene und Neoantigene in genetischen und karzinogen-induzierten Melanom Tumormodellen

Multifunctional nanoscale peptide/glykopeptide conjugates as synthetic vaccines for anti-tumor immunotherapy

AltSpliceMagnaporthe

Integrierte OMICs und Bioinformatik Plattform

Proteine auf Nanocarriern: vom Stealth Effekt zu einem gezielten Targeting in vivo

Rapid evolutionary adaptation: Potential and contraints

Thiol switches controlled by the glutathione-S-transferase GDAP1

Bedeutung von Serum in der GVHD-Entstehung

Publications

Alberg Irina, Kramer Stefan, Schinnerer Meike, Hu Qizhi, Seidl Christine, Leps Christian, Drude Natascha, Moeckel Diana, Rijcken Cristianne, Lammers Twan, Diken Mustafa, Maskos Michael, Morsbach Svenja, Landfester Katharina, Tenzer Stefan, Barz Matthias, Zentel Rudolf
Autoren der Einrichtung: Leps Christian, Tenzer Stefan
Polymeric Nanoparticles with Neglectable Protein Corona
2020; 16 (18):

Alflen Astrid, Lopez Pamela Aranda, Hartmann Ann-Kathrin, Maxeiner Joachim, Bosmann Markus, Sharma Arjun, Platten Johannes, Ries Frederic, Beckert Hendrik, Ruf Wolfram, Radsak Markus P.
Autoren der Einrichtung: Hartmann Ann-Kathrin
Neutrophil extracellular traps impair fungal clearance in a mouse model of invasive pulmonary aspergillosis
2020; 225 (1):

Barthels Fabian, Marincola Gabriella, Marciniak Tessa, Konhaeuser Matthias, Hammerschmidt Stefan, Bierlmeier Jan, Distler Ute, Wich Peter R., Tenzer Stefan, Schwarzer Dirk, Ziebuhr Wilma, Schirmeister Tanja
Autoren der Einrichtung: Distler Ute, Tenzer Stefan
Asymmetric Disulfanylbenzamides as Irreversible and Selective Inhibitors of Staphylococcus aureus Sortase A
2020:

Beissert Tim, Perkovic Mario, Vogel Annette, Erbar Stephanie, Walzer Kerstin C., Hempel Tina, Brill Silke, Haefner Erik, Becker Rene, Tureci Ozlem, Sahin Ugur
Autoren der Einrichtung: Sahin Ugur
A Trans-amplifying RNA Vaccine Strategy for Induction of Potent Protective Immunity
2020; 28 (1): 119-128

Bogucka Katarzyna, Pompaiah Malvika, Marini Federico, Binder Harald, Harm Gregory, Kaulich Manuel, Klein Matthias, Michel Christian, Radsak Markus P., Rosigkeit Sebastian, Grimminger Peter, Schild Hansjoerg, Rajalingam Krishnaraj
Autoren der Einrichtung: Klein Matthias, Schild Hansjoerg
ERK3/MAPK6 controls IL-8 production and chemotaxis
2020; 9:

Bresadola Luisa, Kong Anthony, Loewer Martin, Bukur Valesca, Ritzel Christoph, Weber David, Akilli-Oeztuerk Oeziern, Albrecht Christian, Chu Karen, Mehanna Hisham, Schroers Barbara, Vascotto Fulvia, Sahin Ugur
Autoren der Einrichtung: Sahin Ugur
Comprehensive Genomic and Transcriptomic Analysis of Primary and Recurrent Head and Neck Cancers
2020; 43: 230-230

Distler Ute, Schumann Sven, Kesseler Hans-Georg, Pielot Rainer, Smalla Karl-Heinz, Sielaff Malte, Schmeisser Michael J., Tenzer Stefan
Autoren der Einrichtung: Distler Ute, Sielaff Malte, Tenzer Stefan
Proteomic Analysis of Brain Region and Sex-Specific Synaptic Protein Expression in the Adult Mouse Brain
2020; 9 (2):

Eichel Maria A., Gargareta Vasiliki-Ilya, D'Este Elisa, Fledrich Robert, Kungl Theresa, Buscham Tobias J., Lueders Katja A., Miracle Cristina, Jung Ramona B., Distler Ute, Kusch Kathrin, Moebius Wiebke, Huelsmann Swen, Tenzer Stefan, Nave Klaus-Armin, Werner Hauke B.
Autoren der Einrichtung: Distler Ute, Tenzer Stefan
CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves
2020; 11 (1):

Ferreira Cristina, Barros Leandro, Baptista Marta, Blankenhaus Birte, Barros Andre, Figueiredo-Campos Patricia, Konjar Spela, Laine Alexandra, Kamenjarin Nadine, Stojanovic Ana, Cerwenka Adelheid, Probst Hans C., Marie Julien C., Veldhoen Marc
Autoren der Einrichtung: Kamenjarin Nadine, Probst Hans C.
Type 1 T-reg cells promote the generation of CD8(+) tissue-resident memory T cells
2020; 21 (7): 766-+

Fruehbeis Carsten, Kuo-Elsner Wen Ping, Mueller Christina, Barth Kerstin, Peris Leticia, Tenzer Stefan, Moebius Wiebke, Werner Hauke B., Nave Klaus-Armin, Froehlich Dominik, Kraemer-Albers Eva-Maria
Autoren der Einrichtung: Tenzer Stefan
Oligodendrocytes support axonal transport and maintenance via exosome secretion
2020; 18 (12):

Hauptmann Judith, Johann Lisa, Marini Federico, Kitic Maja, Colombo Elisa, Mufazalov Ilgiz A., Krueger Martin, Karram Khalad, Moos Sonja, Wanke Florian, Kurschus Florian C., Klein Matthias, Cardoso Silvia, Strauss Judith, Bolisetty Subhashini, Luehder Fred, Schwaninger Markus, Binder Harald, Bechman Ingo, Bopp Tobias, Agarwal Anupam, Soares Miguel P., Regen Tommy, Waisman Ari
Autoren der Einrichtung: Bopp Tobias
Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier
2020:

Heimes A. S., Fries P., Stergiou N., Attariya R., Hasenburg A., Schmidt M., Schmitt E., Brenner W.
Autoren der Einrichtung: Fries P., Attariya R., Schmitt E.
(TA)MUC1 as a potential new target for breast cancer therapy
2020; 80 (10): E213-E213

Klein Philipp, Barthels Fabian, Johe Patrick, Wagner Annika, Tenzer Stefan, Distler Ute, Thien Anh Le ?, Schmid Paul, Engel Volker, Engels Bernd, Hellmich Ute A., Opatz Till, Schirmeister Tanja
Autoren der Einrichtung: Tenzer Stefan, Distler Ute
Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics
2020; 25 (9):

Klein Philipp, Johe Patrick, Wagner Annika, Jung Sascha, Kuehlborn Jonas, Barthels Fabian, Tenzer Stefan, Distler Ute, Waigel Waldemar, Engels Bernd, Hellmich Ute A., Opatz Till, Schirmeister Tanja
Autoren der Einrichtung: Tenzer Stefan, Distler Ute
New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the Trypanosoma Protease Rhodesain
2020; 25 (6):

Klemm Patricia, Rajendiran Anandhi, Fragoulis Athanassios, Wruck Christoph, Schippers Angela, Wagner Norbert, Bopp Tobias, Tenbrock Klaus, Ohl Kim
Autoren der Einrichtung: Bopp Tobias
Nrf2 expression driven by Foxp3 specific deletion of Keap1 results in loss of immune tolerance in mice
2020:

Krishnan Aswini, Berthelet Jean, Renaud Emilie, Rosigkeit Sebastian, Distler Ute, Stawiski Eric, Wang Jing, Modrusan Zora, Fiedler Marc, Bienz Mariann, Tenzer Stefan, Schad Arno, Roth Wilfried, Thiede Bernd, Seshagiri Somasekar, Musholt Thomas J., Rajalingam Krishnaraj
Autoren der Einrichtung: Distler Ute, Tenzer Stefan
Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas
2020; 11 (1):

Lang Judith, Bohn Patrick, Bhat Hilal, Jastrow Holger, Walkenfort Bernd, Cansiz Feyza, Fink Julian, Bauer Michael, Olszewski Dominik, Ramos-Nascimento Ana, Duhan Vikas, Friedrich Sarah-Kim, Becker Katrin Anne, Krawczyk Adalbert, Edwards Michael J., Burchert Andreas, Huber Magdalena, Friebus-Kardash Justa, Goethert Joachim R., Hardt Cornelia, Probst Hans Christian, Schumacher Fabian, Koehrer Karl, Kleuser Burkhard, Babiychuk Eduard B., Sodeik Beate, Seibel Juergen, Greber Urs F., Lang Philipp A., Gulbins Erich, Lang Karl S.
Autoren der Einrichtung: Probst Hans Christian
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
2020; 11 (1):

Loquai Carmen, Hassel Jessica Cecile, Oehm Petra, Derhovanessian Evelyna, Jabulowsky Robert Alexander, Gold Maike, Schwarck-Kokarakis Doreen, Attig Sebastian, Cuk Katarina, Vogler Isabel, Sikorski Julian, Leierer Melanie, Mitzel-Rink Heidrun, Miederer Matthias, Grabbe Stephan, Utikal Jochen, Pinter Andreas, Kaufmann Roland, Sahin Ugur, Tureci Oezlem
Autoren der Einrichtung: Attig Sebastian
A shared tumor-antigen RNA-lipoplex vaccine with/without anti-PD1 in patients with checkpoint-inhibition experienced melanoma.
2020; 38 (15):

Mann Caroline, Schmidtmann Irene, Bopp Tobias, Brieger Juergen, Fruth Kai
Autoren der Einrichtung: Bopp Tobias
Treg activation and their role in different subtypes of chronic rhinosinusitis
2020:

Mohebiany Alma Nazlie, Ramphal Nishada Shakunty, Karram Khalad, Di Liberto Giovanni, Novkovic Tanja, Klein Matthias, Marini Federico, Kreutzfeldt Mario, Haertner Franziska, Lacher Sonja Maria, Bopp Tobias, Mittmann Thomas, Merkler Doron, Waisman Ari
Autoren der Einrichtung: Klein Matthias, Bopp Tobias
Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology
2020; 30 (5): 1585-+

Nogueira Sara S., Schlegel Anne, Maxeiner Konrad, Weber Benjamin, Barz Matthias, Schroer Martin A., Blanchet Clement E., Svergun ?, Ramishetti Srinivas, Peer Dan, Langguth Peter, Sahin Ugur, Haas Heinrich
Autoren der Einrichtung: Sahin Ugur
Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery
2020; 3 (11): 10634-10645

Pektor Stefanie, Lawaczeck Laura, Tenzer Stephan, Bausbacher Nicole, Hoffmann Manuela Andrea, Schreckenberger Mathias, Miederer Matthias
Autoren der Einrichtung: Tenzer Stephan
Characterization of activation induced [(18)]F-FDG uptake in Dendritic Cells
2020:

Riegel Kristina, Schloeder Janine, Sobczak Marco, Jonuleit Helmut, Thiede Bernd, Schild Hansjoerg, Rajalingam Krishnaraj
Autoren der Einrichtung: Schild Hansjoerg
RAF kinases are stabilized and required for dendritic cell differentiation and function
2020; 27 (4): 1300-1315

Romero-Olmedo Addi J., Schulz Axel R., Huber Magdalena, Brehm Corinna U., Chang Hyun-Dong, Chiarolla Cristina M., Bopp Tobias, Skevaki Chrysanthi, Berberich-Siebelt Friederike, Radbruch Andreas, Mei Henrik E., Lohoff Michael
Autoren der Einrichtung: Bopp Tobias
Deep phenotypical characterization of human CD3(+)CD56(+) T cells by mass cytometry
2020:

Sadanandam Anguraj, Bopp Tobias, Dixit Santosh, Knapp David J. H. F., Emperumal Chitra Priya, Vergidis Paschalis, Rajalingam Krishnaraj, Melcher Alan, Kannan Nagarajan
Autoren der Einrichtung: Bopp Tobias
A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients
2020; 6 (1):

Sahin Ugur, Oehm Petra, Derhovanessian Evelyna, Jabulowsky Robert A., Vormehr Mathias, Gold Maike, Maurus Daniel, Schwarck-Kokarakis Doreen, Kuhn Andreas N., Omokoko Tana, Kranz Lena M., Diken Mustafa, Kreiter Sebastian, Haas Heinrich, Attig Sebastian, Rae Richard, Cuk Katarina, Kemmer-Brueck Alexandra, Breitkreuz Andrea, Tolliver Claudia, Caspar Janina, Quinkhardt Juliane, Hebich Lisa, Stein Malte, Hohberger Alexander, Vogler Isabel, Liebig Inga, Renken Stephanie, Sikorski Julian, Leierer Melanie, Mueller Verena, Mitzel-Rink Heidrun, Miederer Matthias, Huber Christoph, Grabbe Stephan, Utikal Jochen, Pinter Andreas, Kaufmann Roland, Hassel Jessica C., Loquai Carmen, Tuereci Oezlem
Autoren der Einrichtung: Sahin Ugur, Attig Sebastian
An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma
2020; 585 (7823): 107-+

Salazar Ylia, Zheng Xiang, Brunn David, Raifer Hartmann, Picard Felix, Zhang Yajuan, Winter Hauke, Guenther Stefan, Weigert Andreas, Weigmann Benno, Dumoutier Laure, Renauld Jean-Christophe, Waisman Ari, Schmall Anja, Tufman Amanda, Fink Ludger, Bruene Bernhard, Bopp Tobias, Grimminger Friedrich, Seeger Werner, Pullamsetti Soni Savai, Huber Magdalena, Savai Rajkumar
Autoren der Einrichtung: Bopp Tobias
Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer
2020; 130 (7): 3560-3575

Salomon Nadja, Vascotto Fulvia, Selmi Abderaouf, Vormehr Mathias, Quinkhardt Juliane, Bukur Thomas, Schroers Barbara, Loeewer Martin, Diken Mustafa, Tuereci Oezlem, Sahin Ugur, Kreiter Sebastian
Autoren der Einrichtung: Sahin Ugur
A liposomal RNA vaccine inducing neoantigen-specific CD4(+)T cells augments the antitumor activity of local radiotherapy in mice
2020; 9 (1):

Schaupp Laura, Muth Sabine, Rogell Leif, Kofoed-Branzk Michael, Melchior Felix, Lienenklaus Stefan, Ganal-Vonarburg Stephanie C., Klein Matthias, Guendel Fabian, Hain Tobias, Schuetze Kristian, Grundmann Ulrike, Schmitt Vanessa, Dorsch Martina, Spanier Julia, Larsen Pia-Katharina, Schwanz Thomas, Jaeckel Sven, Reinhardt Christoph, Bopp Tobias, Danckwardt Sven, Mahnke Karsten, Heinz Gitta Anne, Mashreghi Mir-Farzin, Durek Pawel, Kalinke Ulrich, Kretz Oliver, Huber Tobias B., Weiss Siegfried, Wilhelm Christoph, Macpherson Andrew J., Schild Hansjoerg, Diefenbach Andreas, Probst Hans Christian
Autoren der Einrichtung: Muth Sabine, Melchior Felix, Klein Matthias, Hain Tobias, Schuetze Kristian, Bopp Tobias, Schild Hansjoerg, Probst Hans Christian
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells
2020; 181 (5): 1080-+

Scherger Maximilian, Bolli Evangelia, Antunes Ana Rita Pombo, Arnouk Sana, Stickdorn Judith, Van Driessche Alexandra, Schild Hansjorg, Grabbe Stephan, De Geest Bruno G., Van Ginderachter Jo A., Nuhn Lutz
Autoren der Einrichtung: Schild Hansjorg
Transient Multivalent Nanobody Targeting to CD206-Expressing Cells via PH-Degradable Nanogels
2020; 9 (10):

Schmiedeke Julia K., Hartmann Ann-Kathrin, Ruckenbrod Teresa, Stassen Michael, Reddehase Matthias J., Lemmermann Niels A.
Autoren der Einrichtung: Hartmann Ann-Kathrin, Stassen Michael
The Anti-apoptotic Murine Cytomegalovirus Protein vMIA-m38.5 Induces Mast Cell Degranulation
2020; 10:

Schroers Barbara, Boegel Sebastian, Albrecht Christian, Bukur Thomas, Bukur Valesca, Holtstraeter Christoph, Ritzel Christoph, Manninen Katja, Tadmor Arbel D., Vormehr Mathias, Sahin Ugur, Loewer Martin
Autoren der Einrichtung: Vormehr Mathias
Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor Model
2020; 10:

Seitaj Bruno, Maull Felicia, Zhang Li, Wuellner Verena, Wolf Christina, Schippers Philipp, La Rovere Rita, Distler Ute, Tenzer Stefan, Parys Jan B., Bultynck Geert, Methner Axel
Autoren der Einrichtung: Distler Ute, Tenzer Stefan
Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery
2020; 9 (10):

Sethi Riccha, Becker Julia, Graaf Jos de, Loewer Martin, Suchan Martin, Sahin Ugur, Weber David
Autoren der Einrichtung: Sahin Ugur
Integrative analysis of structural variations using short-reads and linked-reads yields highly specific and sensitive predictions
2020; 16 (11):

Sharma Arjun, Klein Matthias, Schuetze Kristian, Murke Florian, Giebel Bernd, Karbach Susanne, Marini Frederico, Bopp Tobias, Visekruna Alexander, Schaefer Katrin, Best Sonja M., Rock Kenneth L., Remick Daniel G., Waisman Ari, Gale ?, Bosmann Markus
Autoren der Einrichtung: Klein Matthias, Schuetze Kristian, Bopp Tobias
MAVS DEFICIENCY CONFERS UNEXPECTED PROTECTION FROM LETHALITY DURING POLYMICROBIAL SEPSIS
2020; 53: 30-31

Thalman Carine, Horta Guilherme, Qiao Lianyong, Endle Heiko, Tegeder Irmgard, Cheng Hong, Laube Gregor, Sigurdsson Torfi, Hauser Maria Jelena, Tenzer Stefan, Distler Ute, Aoki Junken, Morris Andrew J., Geisslinger Gerd, Roeper Jochen, Kirischuk Sergei, Luhmann Heiko J., Radyushkin Konstantin, Nitsch Robert, Vogt Johannes
Autoren der Einrichtung: Tenzer Stefan, Distler Ute
Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders (vol 23, pg 1699, 2018)
2020; 25 (11): 3108-3108

Turonova Beata, Sikora Mateusz, Schuermann Christoph, Hagen Wim J. H., Welsch Sonja, Blanc Florian E. C., von Buelow Soeren, Gecht Michael, Bagola Katrin, Hoerner Cindy, van Zandbergen Ger, Landry Jonathan, de Azevedo Nayara Trevisan Doimo, Mosalaganti Shyamal, Schwarz Andre, Covino Roberto, Muehlebach Michael D., Hummer Gerhard, Locker Jacomine Krijnse, Beck Martin
Autoren der Einrichtung: van Zandbergen Ger
In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges
2020; 370 (6513): 203-+

Uebbing Lukas, Ziller Antje, Siewert Christian, Schroer Martin A., Blanchet Clement E., Svergun ?, Ramishetti Srinivas, Peer Dan, Sahin Ugur, Haas Heinrich, Langguth Peter
Autoren der Einrichtung: Sahin Ugur
Investigation of pH-Responsiveness inside Lipid Nanoparticles for Parenteral mRNA Application Using Small-Angle X-ray Scattering
2020; 36 (44): 13331-13341

Vormehr Mathias, Lehar Sophie, Kranz Lena M., Tahtinen Siri, Oei Yoko, Javinal Vincent, Delamarre Lelia, Walzer Kerstin C., Diken Mustafa, Kreiter Sebastian, Mellman Ira, Sahin Ugur, Schartner Jill M., Tuereci Oezlem
Autoren der Einrichtung: Vormehr Mathias, Diken Mustafa, Sahin Ugur
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
2020; 9 (1):

Woelfinger Pascal, Epp Katharina, Schaefer Lukas, Kriege Diana, Theobald Matthias, Bopp Tobias, Wagner-Drouet Eva-Maria
Autoren der Einrichtung: Bopp Tobias
CD52-negative T cells predict acute graft-versus-host disease after an alemtuzumab-based conditioning regimen
2020; 191 (2): 253-262

Woelfinger Pascal, Epp Katharina, Schaefer Lukas, Kriege Diana, Theobald Matthias, Bopp Tobias, Wagner-Drouet Eva-Maria
Autoren der Einrichtung: Bopp Tobias
CD52-negative T cells predict acute graft-versus-host disease after an alemtuzumab-based conditioning regimen
2020; 191 (2): 253-262

Wolf Christina, del Amo Victor Lopez, Arndt Sabine, Bueno Diones, Tenzer Stefan, Hanschmann Eva-Maria, Berndt Carsten, Methner Axel
Autoren der Einrichtung: Arndt Sabine, Tenzer Stefan
Redox Modifications of Proteins of the Mitochondrial Fusion and Fission Machinery
2020; 9 (4):

Postdoctoral Qualifications

PD Dr. rer. nat. et med. habil. Verena_(Katharina) Raker
Immunregulation entzündlicher Prozesse bei Autoimmunität